Results 31 to 40 of about 5,430,372 (258)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm

Frontiers in Behavioral Neuroscience
This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms.
Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess, Andreas Hess, Andreas Hess   +13 more
doaj   +1 more source

Relations of change in fruit and vegetable intake with overall energy reduction and physical activity with weight change: Assessing theory-based psychosocial mediators

Journal of Sport and Health Science, 2019
Background: Increased physical activity and fruit and vegetable (FV) intake are typically suggested to counter obesity. Sustained behavior change in those areas has, however, been poor, possibly because of a lack of understanding of the effects of ...
James J. Annesi
doaj   +1 more source

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations

Scientific Reports, 2023
A medically important feature of several types of tumors is their ability to “decide” between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate
Shalu Dwivedi, Christina Glock, Sebastian Germerodt, Heiko Stark, Stefan Schuster   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A numerical investigation upon the energy performances of caloric materials working in an Active Regenerator

, 2018
Over the years, experimental and numerical studies have consolidated the potential of the caloric cooling as a technology of tomorrow. The numerous investigations conducted all-over-the-world have shown that the bottleneck in the energy performances of a
DEL DUCA M. G., GRECO A., Masselli C., APREA C., Maiorino A.   +4 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Head circumference as an epigenetic risk factor for maternal nutrition

Frontiers in Nutrition, 2022
Nutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status.
Maria J. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G. Fernandes, Karayna G. Fernandes, Matias C. Vieira, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti, Preterm SAMBA study group   +15 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Time line of redox events in aging postmitotic cells

eLife, 2013
The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present
Nicolas Brandes, Heather Tienson, Antje Lindemann, Victor Vitvitsky, Dana Reichmann, Ruma Banerjee, Ursula Jakob   +6 more
doaj   +1 more source