Results 31 to 40 of about 239 (208)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Time line of redox events in aging postmitotic cells

eLife, 2013
The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present
Nicolas Brandes, Heather Tienson, Antje Lindemann, Victor Vitvitsky, Dana Reichmann, Ruma Banerjee, Ursula Jakob   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Historical analysis of the concept of Heat in Joule`s papers and possible implications for Physical Education

Investigações em Ensino de Ciências, 2017
This paper aimed to carry out an analysis of Joule’s original texts, written in the middle of the XIX century, trying to understand how the changes in heat concept occurred throughout his work. To support the theoretical analysis, a literature review was
Bianca Cintra de Carvalho, Luciano Carvalhais Gomes   +1 more
doaj   +1 more source

Dietary fat supplements influence weight gain and egg production, but not offspring sex ratios in Japanese quail, Coturnix coturnix japonica

Journal of Avian Biology, 2023
Sex ratio theory suggests that females should bias offspring sex ratios based on maternal condition and the availability of critical food resources. Work in birds indicates that females do, indeed, bias sex ratios according to maternal condition and food
James Curry, Woo Yun Kim, Mary T. Mendonça, Kristen J. Navara   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oxi-Inflamm-Aging: a New Theory with Practical Implications

Medisur, 2016
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune dysregulation leads to a chronic low-grade inflammatory state in aging. This is the basis of the new integrative
Ángel Julio Romero Cabrera, Leocadia Amores Hernández   +1 more
doaj   +2 more sources

The nature of heat: after two centuries, will it be that the caloric theory is still in some way an attractive idea or, even, useful?

Semina: Ciências Exatas e Tecnológicas, 2009
In the beginning of the 19th Century, there were two theories absolutely different on the nature of the heat: the Mechanical Theory of the Heat and the Caloric Theory.
Antônio Bráz de Pádua, Cléia Guiotti de Pádua, Ricardo Spagnuolo Martins   +2 more
doaj  

Fiber Optic Sensors for Vital Signs Monitoring. A Review of Its Practicality in the Health Field

Biosensors, 2021
Vital signs not only reflect essential functions of the human body but also symptoms of a more serious problem within the anatomy; they are well used for physical monitoring, caloric expenditure, and performance before a possible symptom of a massive ...
Christian Perezcampos Mayoral, Jaime Gutiérrez Gutiérrez, José Luis Cano Pérez, Marciano Vargas Treviño, Itandehui Belem Gallegos Velasco, Pedro António Hernández Cruz, Rafael Torres Rosas, Lorenzo Tepech Carrillo, Judith Arnaud Ríos, Edmundo López Apreza, Roberto Rojas Laguna   +10 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source