Results 31 to 40 of about 63,636 (293)

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations

Scientific Reports, 2023
A medically important feature of several types of tumors is their ability to “decide” between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate
Shalu Dwivedi, Christina Glock, Sebastian Germerodt, Heiko Stark, Stefan Schuster   +4 more
doaj   +1 more source

Head circumference as an epigenetic risk factor for maternal nutrition

Frontiers in Nutrition, 2022
Nutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status.
Maria J. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G. Fernandes, Karayna G. Fernandes, Matias C. Vieira, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti, Preterm SAMBA study group   +15 more
doaj   +1 more source

The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]

, 2015
This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan, Delville, Camille, Derous, Davina, Douglas, Alex, Green, Cara Leanne, Han, Jackie J.D., Hurst, Jane, Konstantopedos, Penelope, Lusseau, David, Mitchell, Sharon E., Promislow, Daniel E. L., Speakman, John R., Wang, Yingchun   +12 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Understanding the Multifaceted Process of Aging: Theories, Mechanisms, and Implications for Treatment

Al-SalamJournal for Medical Science
The aging process is a multifaceted biological phenomenon characterized by alterations at the molecular, cellular, and organ levels that culminate in a gradual, unavoidable, and unavoidable reduction in the body's capacity to react suitably to internal ...
Omar M. Ameen, Ghada A. Taqa
doaj   +1 more source

Thermodynamic fluctuation relation for temperature and energy

, 2009
The present work extends the well-known thermodynamic relation $C=\beta ^{2}< \delta {E^{2}}>$ for the canonical ensemble. We start from the general situation of the thermodynamic equilibrium between a large but finite system of interest and a ...
Antonov V A, Beck C, Bohr N, Bohr N, Chavanis P H, Gross D H E, Gross D H E, L Velazquez, Landau L D, Landau P D, Landsberg P T, Lynden-Bell D, Lynden-Bell D, Lynden-Bell D, Rosenfeld L, S Curilef, Thirring W, Velazquez L   +17 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm

Frontiers in Behavioral Neuroscience
This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms.
Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess, Andreas Hess, Andreas Hess   +13 more
doaj   +1 more source

Caloric effects around phase transitions in magnetic materials described by ab initio theory: The electronic glue and fluctuating local moments [PDF]

Journal of Applied Physics, 2020
We describe magneto-, baro-, and elastocaloric effects (MCEs, BCEs, and eCEs) in materials, which possess both discontinuous (first-order) and continuous (second-order) magnetic phase transitions. Our ab initio theory of the interacting electrons of materials in terms of disordered local moments has produced explicit mechanisms for the drivers of these
Eduardo Mendive-Tapia, Julie B. Staunton
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source