Results 21 to 30 of about 239 (208)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Understanding the Multifaceted Process of Aging: Theories, Mechanisms, and Implications for Treatment

Al-SalamJournal for Medical Science
The aging process is a multifaceted biological phenomenon characterized by alterations at the molecular, cellular, and organ levels that culminate in a gradual, unavoidable, and unavoidable reduction in the body's capacity to react suitably to internal ...
Omar M. Ameen, Ghada A. Taqa
doaj   +1 more source

Relations of change in fruit and vegetable intake with overall energy reduction and physical activity with weight change: Assessing theory-based psychosocial mediators

Journal of Sport and Health Science, 2019
Background: Increased physical activity and fruit and vegetable (FV) intake are typically suggested to counter obesity. Sustained behavior change in those areas has, however, been poor, possibly because of a lack of understanding of the effects of ...
James J. Annesi
doaj   +1 more source

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations

Scientific Reports, 2023
A medically important feature of several types of tumors is their ability to “decide” between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate
Shalu Dwivedi, Christina Glock, Sebastian Germerodt, Heiko Stark, Stefan Schuster   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm

Frontiers in Behavioral Neuroscience
This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms.
Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess, Andreas Hess, Andreas Hess   +13 more
doaj   +1 more source

Head circumference as an epigenetic risk factor for maternal nutrition

Frontiers in Nutrition, 2022
Nutrition indicators for malnutrition can be screened by many signs such as stunting, underweight or obesity, muscle wasting, and low caloric and nutrients intake. Those deficiencies are also associated with low socioeconomic status.
Maria J. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G. Fernandes, Karayna G. Fernandes, Matias C. Vieira, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti, Preterm SAMBA study group   +15 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions

Frontiers in Aging
Despite decades of research into the molecular hallmarks of aging, geroscience lacks a unifying framework that both coherently integrates evolutionary accounts of aging and is directly useful for intervention assessment. Here, we propose the ‘Aging Onion’
Yusuf Aggour, Roberto Salguero-Gómez, Roberto Salguero-Gómez   +2 more
doaj   +1 more source

Frustrated magnetism and caloric effects in Mn-based antiperovskite nitrides: Ab initio theory [PDF]

Physical Review B, 2017
We model changes of magnetic ordering in Mn-antiperovskite nitrides driven by biaxial lattice strain at zero and at finite temperature. We employ a non-collinear spin-polarised density functional theory to compare the response of the geometrically frustrated exchange interactions to a tetragonal symmetry breaking (the so called piezomagnetic effect ...
Zemen, J., Tapia, E. Mendive, Gercsi, Z., Banerjee, R., Patrick, C. E., Staunton, J. B., Sandeman, K. G.   +6 more
openaire   +3 more sources