Results 31 to 40 of about 14,571 (260)

Caloric effects around phase transitions in magnetic materials described by ab initio theory: The electronic glue and fluctuating local moments [PDF]

open access: yesJournal of Applied Physics, 2020
We describe magneto-, baro-, and elastocaloric effects (MCEs, BCEs, and eCEs) in materials, which possess both discontinuous (first-order) and continuous (second-order) magnetic phase transitions. Our ab initio theory of the interacting electrons of materials in terms of disordered local moments has produced explicit mechanisms for the drivers of these
Eduardo Mendive-Tapia, Julie B. Staunton
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Time line of redox events in aging postmitotic cells

open access: yeseLife, 2013
The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present
Nicolas Brandes   +6 more
doaj   +1 more source

Dietary fat supplements influence weight gain and egg production, but not offspring sex ratios in Japanese quail, Coturnix coturnix japonica

open access: yesJournal of Avian Biology, 2023
Sex ratio theory suggests that females should bias offspring sex ratios based on maternal condition and the availability of critical food resources. Work in birds indicates that females do, indeed, bias sex ratios according to maternal condition and food
James Curry   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Oxi-Inflamm-Aging: a New Theory with Practical Implications

open access: yesMedisur, 2016
Oxidative stress causes an impairment of the physiological systems essential for maintaining homeostasis, including the immune system. Immune dysregulation leads to a chronic low-grade inflammatory state in aging. This is the basis of the new integrative
Ángel Julio Romero Cabrera   +1 more
doaj   +2 more sources

Historical analysis of the concept of Heat in Joule`s papers and possible implications for Physical Education

open access: yesInvestigações em Ensino de Ciências, 2017
This paper aimed to carry out an analysis of Joule’s original texts, written in the middle of the XIX century, trying to understand how the changes in heat concept occurred throughout his work. To support the theoretical analysis, a literature review was
Bianca Cintra de Carvalho   +1 more
doaj   +1 more source

Fiber Optic Sensors for Vital Signs Monitoring. A Review of Its Practicality in the Health Field

open access: yesBiosensors, 2021
Vital signs not only reflect essential functions of the human body but also symptoms of a more serious problem within the anatomy; they are well used for physical monitoring, caloric expenditure, and performance before a possible symptom of a massive ...
Christian Perezcampos Mayoral   +10 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

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