Results 211 to 220 of about 28,252 (277)

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Reconstitution of glycan-driven MHC I recycling reveals calreticulin as mediator between TAPBPR and tapasin

Heinke TJ, Fahim A, Popovic N, Rath T, Morgner N, Trowitzsch S, Tampé R.   +6 more
europepmc   +1 more source

Selective activation of the unfolded protein response and proteolytic pathways in sarcopenic limb muscles of bronchiectasis patients. [PDF]

ERJ Open Res
Núñez-Robainas A, Solano A, Marsico S, Alvarado-Miranda M, Cumpli-Gargallo MC, Sáinz-Hernández M, Maiques JM, Barreiro E.   +7 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of <i>Trypanosoma cruzi</i> trypomastigotes on mammalian cells. [PDF]

Nanomedicine (Lond)
Prestegui-Martel B, Martínez I, Cárdenas-Guerra RE, Cortés-Coss AK, Del Toro-Ríos X, Hernández-Garcia A, Espinoza B.   +6 more
europepmc   +1 more source

Stimuli‐Responsive Aggregation‐Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications

Small Science, Volume 6, Issue 7, July 2026.
pH, enzyme, hypoxia/redox, temperature, and external trigger‐responsive AIE materials for tumor imaging and therapy. Smart‐responsive aggregation‐induced emission (AIE) materials have emerged as promising bio‐nanomaterials for tumor diagnosis and therapy due to their enhanced fluorescence in aggregated states, overcoming the aggregation‐caused ...
Zhaohua Xu, Deyue Kong, Xiaoru Li, Miao Zhu, Haili Yan, Chenyang Zhang, Xiaochun Wang, Duiping Feng, Jiangfeng Du   +8 more
wiley   +1 more source

Ferroptosis in the U87MG Human Glioblastoma Cell Line Induces Damage Associated Molecular Phenotypes. [PDF]

MicroPubl Biol
Neitzel L, Rea S, Cornell J, Williams C, Hong C.   +4 more
europepmc   +1 more source

Cucumber green mottle mosaic virus: A persistent seed‐borne threat to cucurbits

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Cucumber green mottle mosaic virus (CGMMV) is a highly stable, seed‐borne tobamovirus that threatens global cucurbit production. Its efficient mechanical and seed transmission, long‐term environmental persistence, and the spread of Clade II CGMMV isolates drive its rapid dissemination and cause severe yield losses.
Esperanza Gea‐Caballero, Miguel A. Aranda   +1 more
wiley   +1 more source

Targeted hyperthermia therapy (THT) using gold nanorods remodels the tumor microenvironment to sensitize murine microsatellite-stable colorectal cancer to immune checkpoint blockade. [PDF]

J Nanobiotechnology
Kennedy BE, Jordan JL, Subramanian G, Clark KN, Dean C, Cheverie NP, Corscadden KJ, Gormley C, Noftall EB, Hanes MR, Edgar A, Marshall JS, Giacomantonio CA.   +12 more
europepmc   +1 more source

Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom

British Journal of Haematology, Volume 209, Issue 1, Page 160-171, July 2026.
Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas, Gabriel Naylor‐Layland, Clare Brown, Ahmad Alabdulkarim, Jennifer Ryan, Frances Wadelin, Samah Alimam, Phyo Wint Wint Tun, Jonathan Lambert, Jennifer O'Sullivan, Andrew J. Wilson, Laith Tafesh, Andrew McGregor, Simone Claudiani, Andrew Innes, Emily Booth, James Leveson, Steve Knapper, Mamta Garg, Mani Dubey, Theodora Vatopoulou, Charlotte Brierley, Wai Ka Natalie Leung, Graham Greenfield, Mary Frances McMullin, Alesia Khan, Kate Milne, Duncan Brian, Anna Godfrey, Claire N. Harrison, Bethan Psaila, Patrick Harrington, Amy Kirkwood, Tim C. P. Somervaille, Donal P. McLornan, on behalf of the UK Blood Cancer Research Network MPN Clinical Study Group   +35 more
wiley   +1 more source