Results 121 to 130 of about 1,737,953 (277)
Advanced Science, EarlyView.This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi +16 more
wiley +1 more source
Indian Journal of Community MedicineBackground: Cancer being a deadly disease, cancer victims face great challenges with respect to their routines, roles and relationships. The usage of other means to cure illness is called complementary and alternative medicine or CAM.
Gagan A Pai +9 more
doaj +1 more source
Endüstriyel cam üretiminde kullanılan CAD/CAM sistemlerinin sanatsal cam üretimine etkileri
, 2019 Computer-aided design and production systems, which are updated with technological developments, shape the production of industrial glass, but are also included in the artistic glass production by the artists and innovative and creative potentials of these systems are discovered.
openaire +2 more sources
Advanced Science, EarlyView.Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu +12 more
wiley +1 more source
Structural and physico-chemical properties of selected glasses in the (Ca1-xMgx)O-Al2O3 system
Chimica Techno ActaOxide glasses and melts are of interest in many fields of science and technology. The structural and physico-chemical properties of C12A7, C11M1A7, C10M2A7, C9M3A7, and C8M4A7 glasses (C = CaO, M = MgO and A = Al2O3) were studied for the first time.
Anatoly S. Arkhipin +4 more
doaj +1 more source
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Design and experimental verification of the picking cam mechanism for safflower filaments
Mechanics & IndustryA picking head for automated harvesting of safflower filaments is designed to address the low manual harvesting efficiency and scarce automatic harvesting machinery.
Chen Bangbang +4 more
doaj +1 more source
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury
Advanced Science, EarlyView.Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu +11 more
wiley +1 more source
Advanced Science, EarlyView.Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang +5 more
wiley +1 more source
An Open Source Validation System for Continuous Arterial Blood Pressure Measuring Sensors
SensorsThe advancement of sensor technologies enables the measurement of high-quality continuous blood pressure signals, which has become an important area in healthcare. The development of such application-specific sensors can be time-consuming, expensive, and
Attila Répai +3 more
doaj +1 more source