Results 111 to 120 of about 372,964 (306)
Advanced Science, EarlyView.ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan +12 more
wiley +1 more source
Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi DergisiAtık camların düzenli depolanma yöntemi ile bertarafı yaygın kullanılmakta ancak çevresel etkilerinden kaynaklı sıklıkla eleştirilmektedir. Bu çalışmada, düzenli depolamaya bir alternatif olarak farklı oranlarda (%25-%100) atık camın asfalt karışımda ...
Burak Yiğit Katanalp
doaj +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Integrating Acupuncture and Yoga for Pain Management in Knee Osteoarthritis
Interdisciplinary Journal of Epidemiology and Public HealthBackground: Knee osteoarthritis (OA) is a prevalent and debilitating condition. We explore the potential of a multimodal intervention for managing knee OA, combining naturopathic therapies, acupuncture, yoga, and resistance exercise.
Sureshbabu venkatasamy +2 more
doaj +1 more source
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
The Modular Units of CAD/CAM Fabrication
, 2009 After Frank OiGehryis completion of the fish sculpture in Barcelona, the technique of CAD/CAM fabrication has gradually matured. Designers could use computer to acquire the freedom of form without most restrictions.
Cyang Wang
core
Advanced Science, EarlyView.This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen +7 more
wiley +1 more source
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source
Advanced Science, EarlyView.A hierarchically structured Fe‐BTC‐PMA immobilized 3D‐printed platform is engineered as a robust artificial enzyme for colorimetric glucose sensing. The hybrid architecture efficiently activates H2O2 to drive TMB oxidation. This integrated system enables sensitive, reusable, and scalable detection with enhanced catalytic stability and analytical ...
Paramita Koley +10 more
wiley +1 more source
Conversation with Cam Winton, Candidate for Minneapolis Mayor
, 2013 Cam Winton is the only Independent candidate in the Minneapolis Mayoral race. How does his experience and vision for the city differ from those of his DFL counterparts?
Winton, Cam, Jacobs, Lawrence
core