Results 51 to 60 of about 6,035,777 (295)

Philosophy at Cambridge, Newsletter of the Faculty of Philosophy [PDF]

open access: yes, 2007
Philosophy newsletter. Articles by: Jane Heal: From the Chair Jonathan Lear: Radical Hope. Ben Colburn: Philosophy at Cambridge through the Years Lewis Evans; Adrian Boutel: From Law to Philosophy.
Pellegrino, Mariella
core  

Dust and Gas as Seeds for Metal-Poor Star Formation [PDF]

open access: yes, 2008
I address the issue of dust and gas as seeds for metal-poor star formation by reviewing what we know about star formation in nearby dwarf galaxies and its relationship to the gas and dust.
Böttner   +21 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Book review: Africanisation, nationalisation and inequality - mining labor and the Copperbelt in Zambia development [PDF]

open access: yes, 1980
Draft of book review for the Journal of Economic Literature: Africanisation, Nationalisation and Inequality - Mining Labor and the Copperbelt in Zambia Development, by Philip Daniel (Cambridge: Cambridge University Press, 1979)
Seidman, Ann
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Book reviews: On commodifying intangibles [PDF]

open access: yes, 1998
Book reviews of: 1) James Boyle, Shamans, Software, and Spleens: Law and the Construction of the Information Society. Cambridge: Harvard University Press, 1996. Pp. xvi, 270. $35.00 (cloth), $15.95 (paper).
Gordon, Wendy J., Postbrief, Sam
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Review of: Health and Disease in Human History (Robert I. Rotberg ed.) [PDF]

open access: yes, 2001
Review of the book: Health and Disease in Human History: A Journal of Interdisciplinary History Reader (Robert I. Rotberg ed., MIT Press 2000). ISBN 0- 262-18207-6 [345 pp. $25.00 Paper, 5 Cambridge Street, Cambridge, MA 02142]
Cromwell, Terry
core   +1 more source

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