Results 21 to 30 of about 4,959 (171)

A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): In this study, the neutralizing abilities of the equine and the recently introduced camelid antivenoms on the hemodynamic parameters (inotropism, chronotropism, and arrhythmogenicity) were assessed following envenomation by Hemiscorpius ...
Hossein Fatemikia, Mostafa Kamyab, Ali Movahed, Mehdi Sadeghi, Euikyung Kim, Mahdi Behdani, Naser Mohammadpour, Mehrnaz Shahrivar, Ramin Seyedian   +8 more
doaj   +1 more source

Cerebrospinal Nematodiasis in 20 Camelids [PDF]

Journal of Veterinary Internal Medicine, 2016
BackgroundInformation about the clinical and clinicopathologic aspects of cerebrospinal nematodiasis (CN) in camelids is limited.HypothesisClinical and therapeutic variables will be identified as factors predictive of survival.AnimalsClient‐owned camelids suspected of havingCNadmitted to Purdue University between 1995 and 2015.MethodsA retrospective ...
Bertin, F. R., Taylor, S. D.
openaire   +3 more sources

Camelid immunoglobulins and nanobody technology [PDF]

Veterinary Immunology and Immunopathology, 2009
It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-chain antibodies (HCAbs) are expressed after a V-D-J rearrangement and require dedicated constant gamma ...
Muyldermans, S, Baral, TN, Retarnozzo, VC, De Baetselier, P, De Genst, E, Kinne, J, Leonhardt, H, Magez, Stefan, Nguyen, VK, Revets, H, Rothbauer, U, Stijemans, B, Tillib, S, Wernery, U, Wyns, L, Hassanzadeh-Ghassabeh, G, Saerens, D   +16 more
openaire   +5 more sources

Hypoosmotic swelling test in alpaca (Vicugna pacos) spermatozoa recovered the vas deferens [PDF]

SPERMOVA, 2015
The study objective was to evaluate the endosmotic reaction in 5 hypoosmotic solutions 100, 125, 150, 175 and 200 mOsm/l (HOS test) incubated 5 and 15 minutes using alpaca sperm recovered the vas deferens.
Quispe HA, Ciprián R, Ordoñez C, Ampuero E, Cucho H   +4 more
doaj   +1 more source

Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain

Emerging Infectious Diseases, 2023
Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which
Jordi Rodon, Anna Z. Mykytyn, Nigeer Te, Nisreen M.A. Okba, Mart M. Lamers, Lola Pailler-García, Guillermo Cantero, Irina Albulescu, Berend-Jan Bosch, Malik Peiris, Albert Bensaid, Júlia Vergara-Alert, Bart L. Haagmans, Joaquim Segalés   +13 more
doaj   +1 more source

Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview

Frontiers in Immunology, 2017
Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements as they combine the advantages of the specificity and affinity found in conventional antibodies with high stability and solubility.
Ellen R. Goldman, Jinny L. Liu, Dan Zabetakis, George P. Anderson   +3 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Developing drug-like single-domain antibodies (VHH) from in vitro libraries

mAbs
Here, we describe a new VHH library for therapeutic discovery which optimizes humanness, stability, affinity, diversity, developability, and facile purification using protein A in the absence of an Fc domain.
M. Frank Erasmus, Andre A. R. Teixeira, Esteban Molina, Luis Antonio Rodriguez Carnero, Jianquan Li, David Knight, Roberto Di Niro, Camila Leal-Lopes, Adeline Fanni, Hallie Troell, Ashley DeAguero, Laura Spector, Sara D’Angelo, Fortunato Ferrara, Andrew R. M. Bradbury   +14 more
doaj   +1 more source

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

mAbs, 2020
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently,
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka   +6 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source