Results 41 to 50 of about 8,051 (219)

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Co-expression of Factor VIII with anti-FVIII Camelid antibody ligands: Effect on expression levels of bio-therapeutic FVIII [PDF]

, 2015
Production of recombinant FVIII, the protein that is missing or dysfunctional in haemophilia A patients, is highly inefficient compared to other recombinant clotting factors such as FIX.
Tolley, Caroline
core  

Basal Levels and hCG Responses of Serum Testosterone and Estrogen in Male Alpacas

Frontiers in Veterinary Science, 2020
Steroid response to human Chorionic Gonadotropin (hCG) administration has been used in various species to study testicular function and for diagnostic purposes.
Aymen El Zawam, Ahmed Tibary, Cristian Patino   +2 more
doaj   +1 more source

Early embryonic death in Equines and Camelids

Open Veterinary Journal, 2022
This paper includes the study about early embryonic death, predisposing factors of early embryonic death and treatment. Early embryonic death refers to the fetal mortality which varies in mare and camelids but most probably not later than 50 days of gestation.
Rehan Ashraf, Saba Rashid, Imaad Rasheed, Sana Asif   +3 more
openaire   +4 more sources

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Bacteria identified from deep nasopharyngeal swabs and non-endoscopic bronchoalveolar lavage in calves on farms with a history of bronchopneumonia

Acta Veterinaria Scandinavica
Background We describe the occurrence of bacteria associated with bovine respiratory disease (BRD) on Austrian beef operations and compare bacterial culture results from double guarded deep nasopharyngeal swab (DNS) and non-endoscopic bronchoalveolar ...
Jasmin Laschinger, Joachim Spergser, Benedikt Taxacher, Thomas Wittek, Katharina Lichtmannsperger   +4 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Single-domain antibody fragments derived from heavy-chain antibodies: a review

Veterinární Medicína, 2012
Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents.
L. Eyer, K. Hruska
doaj   +1 more source

The “costly son” hypothesis: Sons exacerbate obstetrical dilemmas in humans and other mammals

The Anatomical Record, EarlyView.
Abstract Human childbirth has often been considered uniquely difficult among mammals, yet recent evidence suggests that obstructed labor and fetopelvic disproportion are widespread across placental mammals. Here, we propose the “costly son” hypothesis: because male offspring are typically larger at birth, they impose greater obstetric risk on mothers ...
Nicole D. S. Grunstra, Jonathan C. K. Wells   +1 more
wiley   +1 more source

Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin

Antibodies, 2017
Previously, our group isolated and evaluated anti-ricin single domain antibodies (sdAbs) derived from llamas, engineered them to further increase their thermal stability, and utilized them for the development of sensitive immunoassays. In work focused on
Kendrick B. Turner, Sabrina Hardy, Jinny L. Liu, Dan Zabetakis, P. Audrey Brozozog Lee, Ellen R. Goldman, George P. Anderson   +6 more
doaj   +1 more source