Results 31 to 40 of about 5,170 (185)
Characterisation of the Faecal Microbiome of Alpacas Raised in South Eastern Australia
AnimalsThere is limited investigation of the alpaca microbiome on a global scale, with no previous research conducted in Australia characterising the faecal microbiome.
Imogen Boughey +4 more
doaj +1 more source
Bilateral thyroid adenomas in an alpaca
Journal of Veterinary Internal Medicine, 2021 A 7‐year‐old neutered male alpaca (Vicugna pacos) was presented for evaluation of a 3‐year history of large, bilateral, firm ventral cervical masses causing esophageal and tracheal impingement.
Kate Burbery +3 more
doaj +1 more source
Camelid immunoglobulins and nanobody technology [PDF]
Veterinary Immunology and Immunopathology, 2009 It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-chain antibodies (HCAbs) are expressed after a V-D-J rearrangement and require dedicated constant gamma ...
Muyldermans, S +16 more
openaire +5 more sources
Developing drug-like single-domain antibodies (VHH) from in vitro libraries
mAbsHere, we describe a new VHH library for therapeutic discovery which optimizes humanness, stability, affinity, diversity, developability, and facile purification using protein A in the absence of an Fc domain.
M. Frank Erasmus +14 more
doaj +1 more source
Frontiers in Genetics, 2019 Structural chromosome abnormalities, such as translocations and inversions occasionally occur in all livestock species and are typically associated with reproductive and developmental disorders.
Malorie P. Baily +4 more
doaj +1 more source
Hypoosmotic swelling test in alpaca (Vicugna pacos) spermatozoa recovered the vas deferens [PDF]
SPERMOVA, 2015 The study objective was to evaluate the endosmotic reaction in 5 hypoosmotic solutions 100, 125, 150, 175 and 200 mOsm/l (HOS test) incubated 5 and 15 minutes using alpaca sperm recovered the vas deferens.
Quispe HA +4 more
doaj +1 more source
Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain
Emerging Infectious Diseases, 2023 Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which
Jordi Rodon +13 more
doaj +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
Humans are not unique: difficult birth is common in placental mammals
Biological Reviews, EarlyView.ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley +1 more source