Results 31 to 40 of about 12,569 (240)

An Autosomal Translocation 73,XY,t(12;20)(q11;q11) in an Infertile Male Llama (Lama glama) With Teratozoospermia

Frontiers in Genetics, 2019
Structural chromosome abnormalities, such as translocations and inversions occasionally occur in all livestock species and are typically associated with reproductive and developmental disorders.
Malorie P. Baily, Felipe Avila, Pranab J. Das, Michelle A. Kutzler, Terje Raudsepp   +4 more
doaj   +1 more source

Developing drug-like single-domain antibodies (VHH) from in vitro libraries

mAbs
Here, we describe a new VHH library for therapeutic discovery which optimizes humanness, stability, affinity, diversity, developability, and facile purification using protein A in the absence of an Fc domain.
M. Frank Erasmus, Andre A. R. Teixeira, Esteban Molina, Luis Antonio Rodriguez Carnero, Jianquan Li, David Knight, Roberto Di Niro, Camila Leal-Lopes, Adeline Fanni, Hallie Troell, Ashley DeAguero, Laura Spector, Sara D’Angelo, Fortunato Ferrara, Andrew R. M. Bradbury   +14 more
doaj   +1 more source

Hypoosmotic swelling test in alpaca (Vicugna pacos) spermatozoa recovered the vas deferens [PDF]

SPERMOVA, 2015
The study objective was to evaluate the endosmotic reaction in 5 hypoosmotic solutions 100, 125, 150, 175 and 200 mOsm/l (HOS test) incubated 5 and 15 minutes using alpaca sperm recovered the vas deferens.
Quispe HA, Ciprián R, Ordoñez C, Ampuero E, Cucho H   +4 more
doaj   +1 more source

Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain

Emerging Infectious Diseases, 2023
Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which
Jordi Rodon, Anna Z. Mykytyn, Nigeer Te, Nisreen M.A. Okba, Mart M. Lamers, Lola Pailler-García, Guillermo Cantero, Irina Albulescu, Berend-Jan Bosch, Malik Peiris, Albert Bensaid, Júlia Vergara-Alert, Bart L. Haagmans, Joaquim Segalés   +13 more
doaj   +1 more source

Camelids and sustainable development [PDF]

, 2015
Face to the global changes and new climatic constraints, the camel farming is confronted to new challenges, first to contribute to the “livestock revolution” (for reaching the requirements of a growing human population), especially in remote places of ...
Faye, Bernard
core  

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Bacteria identified from deep nasopharyngeal swabs and non-endoscopic bronchoalveolar lavage in calves on farms with a history of bronchopneumonia

Acta Veterinaria Scandinavica
Background We describe the occurrence of bacteria associated with bovine respiratory disease (BRD) on Austrian beef operations and compare bacterial culture results from double guarded deep nasopharyngeal swab (DNS) and non-endoscopic bronchoalveolar ...
Jasmin Laschinger, Joachim Spergser, Benedikt Taxacher, Thomas Wittek, Katharina Lichtmannsperger   +4 more
doaj   +1 more source

Serological Survey of Antibodies to Mannheimia haemolytica and Pasteurella multocida in Camelids from Argentina [PDF]

, 2017
South American camelids are a source of livestock wealth in Andean countries. In Argentina,there is little information about camelid pathogens, and most of the literature data available areseroprevalence works against virus.
Calcagno, M. L., Canellada, Andrea Mercedes, Castro, Marisa Silvia, Díaz, Ailén Magalí, Ledesma, Martin Manuel, Leoni, Juliana, Manghi, Marcela Alejandra   +6 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source