Results 51 to 60 of about 646,261 (261)

Charting Endocrine Progenitors Across Species and Organs

open access: yesAdvanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing   +21 more
wiley   +1 more source

Camp Wolters - Texas

open access: yes, 1945
Illustrated here is a panoramic view of Camp Wolters, Texas. Labels on photograph identify (left to right) Area No. 4, Sports Arena, Service Club, Area No. 5, Area No. 3, Area No. 2, and Area No.1.
Camp Wolters Studio
core  

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Camp Pike and Camp Robinson collection [DIGITAL CONTENT]

open access: yes, 1917
This collection contains documents, a photograph album, building plans and memorabilia related to activities at Camp Pike/Camp Robinson during World War I and World War ...
Central Arkansas Library System. Butler Center for Arkansas Studies. (Little Rock, Ark.)
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo   +14 more
wiley   +1 more source

СПРИЙНЯТТЯ ОДНЕ ОДНОГО В КОНТЕКСТІ СТАНОВЛЕННЯ ОСОБИСТОСТІ. ПРОБЛЕМНЕ ДОСЛІДЖЕННЯ / PERCEPTION OF ONE ANOTHER IN THE CONSTRUCTION OF THE SELF. CASE STUDY

open access: yesАктуальні питання суспільних наук та історії медицини, 2017
Анотація. У статті розглядається, як мова будує художню і етнічну ідентичність рік до, під час і після досвіду концтаборів, в книзі автобіографічного змісту Аарона Аппельфельдта «Історія життя». Мови його дитинства: німецька (рідна мова), ідиш (мова його
Кармен Деребуш
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

open access: yesAdvanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin   +9 more
wiley   +1 more source

Adenosine A2A receptor agonists with potent antiplatelet activity

open access: yesPlatelets, 2018
Selected adenosine A2A receptor agonists (PSB-15826, PSB-12404, and PSB-16301) have been evaluated as new antiplatelet agents. In addition, radioligand-binding studies and receptor-docking experiments were performed in order to explain their differential
Eduardo Fuentes   +6 more
doaj   +1 more source

C.C.C. camp; Soapstone camp; Nels J. Bogh

open access: yes, 1934
Soapstone Camp F-6, located in Summit County near Kamas Utah. (Out of this camp, the Civilian Conservation Corps built the Mirror Lake Highway during the 1930s.
Bogh, Nels J.
core  

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