Results 51 to 60 of about 1,737,217 (304)
Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition
Platelets, 2020 Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia.
Ngan Thi Tran +4 more
doaj +1 more source
A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. [PDF]
, 2019 Cellular levels of the versatile second messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein-coupled receptors (GPCRs) and attenuated by phosphodiesterases (
Getz, Michael +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Cells, 2020 Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner +4 more
doaj +1 more source
New Jewish Specialty Camps: From Idea to realIty [PDF]
, 2014 Informing Change's evaluation of the Incubator and its camps from 2009 to 2013 addressed five questions, which examined whether and how:1. The new camps had expanded available opportunities for Jewish youth to attend camp 2.
Ellen Irie, Sheila Wilcox, Tina Cheplick
core
Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents
Advanced Healthcare Materials, EarlyView.Postoperative gastric leaks are often treated with off‐label biliary double‐pigtail stents, yet conventional extruded designs are not optimized for leak anatomy, can migrate, and may limit abscess evacuation. PETALS is introduced to optimize transmural drainage geometry and enable patient‐specific 3D‐printable stents.
Parima Phowarasoontorn +14 more
wiley +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Європейські історичні студії, 2018 The article analyzes the conditions of stay and the main manifestations of the cultural and educational activities of interned Ukrainian soldiers in the camp of Alexandriv (Poland) in 1921. Based on the use of a wide range of archival sources, the author
Іhor Sribnyak
doaj +1 more source
Additive Manufacturing of Patient‐Specific Intracranial Aneurysm Cell Culture Models
Advanced Materials Technologies, EarlyView.Patient‐specific intracranial aneurysm models were fabricated using chocolate moulding, 3D printed water‐soluble cores, and direct resin 3D printing. Moulding PDMS around sacrificial cores made of chocolate or 3D printed water‐soluble resin yielded accurate, expandable, and endothelializable models that outperformed resin‐based approaches.
Chloe M. de Nys +6 more
wiley +1 more source
Role of cyclic AMP in the control of cell-specific gene expression [PDF]
, 1993 Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
core +1 more source