Results 61 to 70 of about 283,299 (265)
Advanced Science, EarlyView.An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong +14 more
wiley +1 more source
Redneck Riviera : kitsch et détournement amusé dans l’imaginaire de John Waters
Revue LISA, 2017 Movies by John Waters always feel out of place, neither fully highbrow nor part of the classic underground cinema, they seem to walk a tight rope between avant-garde and exploitation.
Justin S. Wadlow
doaj +1 more source
Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Advanced Science, EarlyView.Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li +9 more
wiley +1 more source
Advanced Science, EarlyView.RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao +14 more
wiley +1 more source
TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes
Advanced Science, EarlyView.In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang +11 more
wiley +1 more source
Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu +10 more
wiley +1 more source
Przez język ukrycia po słowo na „g”. Kim są bohaterowie czasów queer before gay?
Poznańskie Studia Slawistyczne, 2019 Who (and what) was silent about the story told by heteronormative society? And how is the fragment of this story seen by “Others”? The article shows that the time of “queer before gay” includes (in Polish) not only well-known names such as: aunt or pedal,
Tomasz Łukasz Nowak
doaj +1 more source
Modernism/modernity, 2016 If perversion is the last word in certainty, then camp has the last word in uncertainty. Camp agrees with Edith Sitwell insofar as “good taste is one of the worst vices ever invented.”59 When Melissa Bradshaw tells us that “out damned spot” is instead “an issue of make-up, or a wardrobe malfunction,” we discover that camp is a form of critique, not a ...
openaire +3 more sources
Reconfigurable Inflatables Through Controlled Surface Crumpling
Advanced Science, EarlyView.ABSTRACT Inflatable structures offer remarkable versatility due to their compact storage and rapid deployment, making them ideal for lightweight, quickly assembled, and deployable applications. These structures are typically made from membranes that are nearly inextensible yet highly flexible.
Yi Yang +8 more
wiley +1 more source