Results 81 to 90 of about 1,737,217 (304)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A (Camp) Flavour of Camp

Altre Modernità, 2013
[Fabio Cleto (ed.), Pop ‘camp’, Milano, Marcos y Marcos, 2008, 2 vols., 637 pp. ISBN 978-88-7168-449-9, ISBN 978-88-7168-493-2]
openaire   +4 more sources

Kopciuszek i Sarmaci. Kamp w polskim i norweskim dramacie współczesnym

InterAlia
The 1964 publication of Susan Sontag’s essay “Notes on ‘Camp’” initiated a discussion of a phenomenon whose functioning in the mass consciousness was inevitably linked to the process of its cultural appropriation, which had been going on for more than ...
Anna Artwich
doaj   +1 more source

Myra Breckinridge et le passager clandestin. Kitsch, camp et inconscient hollywoodien

Revue LISA, 2017
Strongly criticised for its bad taste upon release, Myra Breckinridge (Michael Sarne, Fox, 1970) was a commercial disaster. It was later rehabilitated as a cult movie thanks to a cultural reevaluation which has considered this narrative experimentation ...
Grégoire Halbout
doaj   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Redneck Riviera : kitsch et détournement amusé dans l’imaginaire de John Waters

Revue LISA, 2017
Movies by John Waters always feel out of place, neither fully highbrow nor part of the classic underground cinema, they seem to walk a tight rope between avant-garde and exploitation.
Justin S. Wadlow
doaj   +1 more source

Competitive cAMP antagonists for cAMP-receptor proteins.

Journal of Biological Chemistry, 1984
The two exocyclic oxygen atoms at phosphorus of cAMP have been replaced by a sulfur atom or by a dimethylamino group. These substitutions introduce chirality at the phosphorus atom; therefore, two diastereoisomers are known for each derivative: (SP)-cAMPS, (RP)-cAMPS, (SP)-cAMPN(CH3)2, and RP-cAMPN(CH3)2.
Haastert, Peter J.M. van, Driel, Roel van, Jastorff, Bernd, Baraniak, Janina, Stec, Wojciech J., Wit, René J.W. de   +5 more
openaire   +3 more sources

Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. [PDF]

, 1983
Treatment of mouse lymphoma S49 cells with D,L-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, depleted cellular polyamine levels and stopped cell growth. The cells were arrested predominantly in G1.
Coffino, P, Marton, LJ, McConlogue, LC
core  

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source