Results 61 to 70 of about 1,724,681 (307)

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier   +7 more
wiley   +1 more source

Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors [PDF]

open access: yes, 2002
Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.
Grandy, David K.   +6 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

open access: yesAdvanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]

open access: yes, 2012
Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Amsen   +35 more
core   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

open access: yesAdvanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin   +18 more
wiley   +1 more source

Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. [PDF]

open access: yes, 1983
Treatment of mouse lymphoma S49 cells with D,L-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, depleted cellular polyamine levels and stopped cell growth. The cells were arrested predominantly in G1.
Coffino, P, Marton, LJ, McConlogue, LC
core  

Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]

open access: yes, 2007
Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie   +11 more
core   +2 more sources

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

open access: yesAdvanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister   +14 more
wiley   +1 more source

СПРИЙНЯТТЯ ОДНЕ ОДНОГО В КОНТЕКСТІ СТАНОВЛЕННЯ ОСОБИСТОСТІ. ПРОБЛЕМНЕ ДОСЛІДЖЕННЯ / PERCEPTION OF ONE ANOTHER IN THE CONSTRUCTION OF THE SELF. CASE STUDY

open access: yesАктуальні питання суспільних наук та історії медицини, 2017
Анотація. У статті розглядається, як мова будує художню і етнічну ідентичність рік до, під час і після досвіду концтаборів, в книзі автобіографічного змісту Аарона Аппельфельдта «Історія життя». Мови його дитинства: німецька (рідна мова), ідиш (мова його
Кармен Деребуш
doaj   +1 more source

“The Vast Experiment”: The New Brunswick Militia’s 1865 Camp of Instruction [PDF]

open access: yes, 2012
In July 1865, almost 1,000 New Brunswick militiamen assembled in Fredericton for a twenty-four day Camp of Instruction. This was the first time peacetime militia training on this scale was ever attempted in British North America.
Wilson, J. Brent
core   +1 more source

Home - About - Disclaimer - Privacy