Results 91 to 100 of about 83,933 (315)
A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae [PDF]
, 2023 Lucas Walker +5 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan +12 more
wiley +1 more source
Amiodarone compared with iodine exhibits a potent and persistent inhibitory effect on TSH-stimulated cAMP production in vitro: a possible mechanism to explain amiodarone-induced hypothyroidism [PDF]
, 1999 V Pitsiavas, Peter Smerdely, SC Boyages
openalex +1 more source
Advanced Science, EarlyView.A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo +10 more
wiley +1 more source
Adrenergic Regulation of the Distribution of Transducer of Regulated cAMP-Response Element-Binding Protein (TORC2) in Rat Pinealocytes [PDF]
, 2011 Richard Kanyo +4 more
openalex +1 more source
Advanced Science, EarlyView.This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley +1 more source
A cAMP/CRP-controlled mechanism for the incorporation of extracellular ADP-glucose in Escherichia coli involving NupC and NupG nucleoside transporters [PDF]
, 2018 Goizeder Almagro +6 more
openalex +1 more source
Advanced Science, EarlyView.Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng +6 more
wiley +1 more source
Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D [PDF]
, 2018 Emely Thompson +2 more
openalex +1 more source
Advanced Science, EarlyView.TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu +7 more
wiley +1 more source