Results 171 to 180 of about 43,494 (228)
Some of the next articles are maybe not open access.
Drugs, 2002
Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
openaire +3 more sources
Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
openaire +3 more sources
The Lancet, 2003
Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
openaire +2 more sources
Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
openaire +2 more sources
Camptothecin: Current Perspectives
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Craig J, Thomas +2 more
openaire +2 more sources
Journal of Medicinal Chemistry, 1975
Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
openaire +2 more sources
Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
openaire +2 more sources
Pharmaceutical Research, 2002
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
openaire +2 more sources
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
openaire +2 more sources
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma
Experimental Cell Research, 2020Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Unfortunately, chemo-resistance is a huge obstacle in the treatment of OS. However, the underlying molecular mechanisms of OS chemo-resistance still remain unknown.
Xingkai, Zhao +3 more
openaire +2 more sources
Review Camptothecin: Current Perspectives
Current Medicinal Chemistry, 2006The review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor agent that targets topoisomerase I. Thousands of CPT derivatives have been synthesized. Two of them, Topotecan and Irinotecan, are commercially approved for use in clinic as antitumor agents while more are still in clinic trials ...
Qing-Yong, Li +3 more
openaire +2 more sources
Camptothecins in clinical development
Expert Opinion on Investigational Drugs, 2004Following the realisation that DNA topoisomerase I is a useful therapeutic target to be exploited for the design of potential inhibitors, topoisomerase I inhibitors now represent an established class of effective agents. In spite of intense efforts in the field, only camptothecins have a clinical relevance.
Franco, Zunino, Graziella, Pratesi
openaire +2 more sources
Pharmacology of Camptothecin Esters
Annals of the New York Academy of Sciences, 2000Abstract: An intact lactone ring of camptothecins is a structural requirement for their anticancer activity. Propionate esters of camptothecin (CPT) and 9‐nitrocamptothecin (9NC), CZ48 and CZ112, respectively, have been synthesized as derivatives resistant to lactone hydrolysis and are chemotherapeutically active.
J G, Liehr +4 more
openaire +2 more sources