Results 201 to 210 of about 39,854 (281)
Some of the next articles are maybe not open access.
Process Biochemistry, 2021
Attenuating the biosynthetic potency of camptothecin producing fungi with the multiple subculturing and storage is the major challenge that limits the scaling-up of this approach.
Ashraf S A El-Sayed +2 more
exaly +2 more sources
Attenuating the biosynthetic potency of camptothecin producing fungi with the multiple subculturing and storage is the major challenge that limits the scaling-up of this approach.
Ashraf S A El-Sayed +2 more
exaly +2 more sources
The recent developments of camptothecin and its derivatives as potential anti-tumor agents.
European journal of medicinal chemistry, 2023This review article focuses on the research progress made in the structural modifications of camptothecin (CPT), a potent cytotoxic natural alkaloid. CPT possesses a unique 5-fused ring structure and exhibits various beneficial activities such as anti ...
Xianzhang Wang +4 more
semanticscholar +1 more source
Stimulus‐Responsive Nano‐Prodrug Strategies for Cancer Therapy: A Focus on Camptothecin Delivery
Small Methods, 2023Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against various cancers. However, its clinical application is severely limited by poor water solubility, easy inactivation, and severe toxicity.
Bingyang Chu +4 more
semanticscholar +1 more source
Drugs, 2002
Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
+7 more sources
Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
+7 more sources
Journal of Integrative Plant Biology, 2022
Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown.
Xiaolong Hao +12 more
semanticscholar +1 more source
Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown.
Xiaolong Hao +12 more
semanticscholar +1 more source
Anti-Cancer Agents in Medicinal Chemistry, 2022
Over the past 55 years of research, various experimental methods have been developed for the total synthesis of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives.
V. Bacherikov
semanticscholar +1 more source
Over the past 55 years of research, various experimental methods have been developed for the total synthesis of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives.
V. Bacherikov
semanticscholar +1 more source
The Lancet, 2003
Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
openaire +2 more sources
Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
openaire +2 more sources
Journal of Medicinal Chemistry, 1975
Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
openaire +2 more sources
Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
openaire +2 more sources