Results 211 to 220 of about 39,854 (281)
Some of the next articles are maybe not open access.
Current advances of endophytes as a platform for production of anti-cancer drug camptothecin.
Food and Chemical Toxicology, 2021Camptothecin (CPT), a well-known monoterpenoid indole alkaloid with broad-spectrum anti-cancer activity, is produced from plants and endophytes. In view of the limitations of plants as sources of camptothecin in productivity and efficiency, endophytes ...
Qingyan Ruan +7 more
semanticscholar +1 more source
Materials Science and Engineering C: Materials for Biological Applications, 2021
Biocompatible polymer-coated magnetic nanoparticles are designed with an objective to sharp-shoot cancer by loading anticancer drugs on them and delivering to the target site.
Kiruthiga Kaliyamoorthy +5 more
semanticscholar +1 more source
Biocompatible polymer-coated magnetic nanoparticles are designed with an objective to sharp-shoot cancer by loading anticancer drugs on them and delivering to the target site.
Kiruthiga Kaliyamoorthy +5 more
semanticscholar +1 more source
Camptothecin: Current Perspectives
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Craig J, Thomas +2 more
openaire +2 more sources
European journal of pharmaceutics and biopharmaceutics, 2020
Simultaneous drug and gene delivery to cancer cells has been introduced to provide advantages of the synergistic effects of gene to sensitize the cancer cells to chemotherapeutic agent.
M. Babaei +6 more
semanticscholar +1 more source
Simultaneous drug and gene delivery to cancer cells has been introduced to provide advantages of the synergistic effects of gene to sensitize the cancer cells to chemotherapeutic agent.
M. Babaei +6 more
semanticscholar +1 more source
Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth.
Angewandte Chemie, 2019Most chemotherapeutics are hydrophobic molecules and need to be converted into hydrophilic form before administration. Based on the excellent hydrophilicity and programmability of DNA, herein, we report a general strategy to construct a precise drug ...
Jiao Zhang +5 more
semanticscholar +1 more source
, 2020
Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to produce camptothecin.
M. Shi +6 more
semanticscholar +1 more source
Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to produce camptothecin.
M. Shi +6 more
semanticscholar +1 more source
Mechanisms of Resistance to Camptothecins
Annals of the New York Academy of Sciences, 2000Abstract:Camptothecins are broad‐spectrum anticancer drugs that specifically target DNA topoisomerase I. Although the availability of camptothecins has had a significant impact on cancer therapeutics, de novo or acquired clinical resistance to camptothecins is common.
A, Saleem +3 more
openaire +2 more sources
, 2020
This paper fortifies the idea of smart drug vehicles, by exploring nickel ferrite nanoparticles. The material is made smart by covering with a novel biocompatible dextran fastened with a hydrophobic cavity containing molecule, β-cyclodextrin (β-CD).
Sivaraj Ramasamy +2 more
semanticscholar +1 more source
This paper fortifies the idea of smart drug vehicles, by exploring nickel ferrite nanoparticles. The material is made smart by covering with a novel biocompatible dextran fastened with a hydrophobic cavity containing molecule, β-cyclodextrin (β-CD).
Sivaraj Ramasamy +2 more
semanticscholar +1 more source
Pharmaceutical Research, 2002
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
openaire +2 more sources
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
openaire +2 more sources
Mechanism of Action of Camptothecin
Annals of the New York Academy of Sciences, 2000Abstract:Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo‐I, resulting in accumulation of a covalent ...
Liu, L.F. +5 more
openaire +2 more sources