Results 221 to 230 of about 233,434 (291)

Designing a systemic intervention for student loneliness and social connectedness using a mixed-methods, co-creation approach. [PDF]

open access: yesNpj Ment Health Res
Homer SR   +8 more
europepmc   +1 more source

An analysis of pediatric retinoblastoma medical malpractice litigation. [PDF]

open access: yesPLoS One
Miller V   +5 more
europepmc   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

open access: yesAngewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić   +27 more
wiley   +1 more source

Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation

open access: yesAngewandte Chemie, EarlyView.
Unlocking gallyl nucleophiles: Counterion control enables formation of an unsupported gallyl─gold complex. Gold coordination induces a polarity switch at gallium, enabling cooperative activation of NH3 and related N─H/O─H substrates under mild conditions.
Hellen Videa   +3 more
wiley   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

open access: yesAngewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne   +5 more
wiley   +1 more source

Electroenzymatic CO2 Fixation

open access: yesAngewandte Chemie International Edition, EarlyView.
Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada   +4 more
wiley   +1 more source

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