Results 41 to 50 of about 5,029,625 (337)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

La Comercialización Internacional del Turismo Comunitario. La Experiencia en América Latina

ARA: Revista de Investigación en Turismo, 2017
En el debate sobre la viabilidad del turismo comunitario se ha reconocido que la comercialización es un factor clave para sus posibilidades de éxito.
Ernest Cañada
doaj  

Predicting COVID-19 trends in Canada: a tale of four models

Cognitive Computation and Systems, 2020
This study aims to offer multiple-model informed predictions of COVID-19 in Canada, specifically through the use of deep learning strategy and mathematical prediction models including long-short term memory network, logistic regression model, Gaussian ...
Wandong Zhang, W.G. (Will) Zhao, Dana Wu, Yimin Yang   +3 more
doaj   +1 more source

Exuberance, A Motivation for Language [PDF]

, 1988
The following is part of the presidential address from Allen Walker Read, given before LACUS (Linguistic Association of Canada and the United States) at its annual meeting, August 7, 1987, at York University, Toronto, Ontario, Canada. It is reprinted by
Read, Allen Walker
core   +1 more source

Meeting report : 1st international functional metagenomics workshop May 7–8, 2012, St. Jacobs, Ontario, Canada [PDF]

, 2012
This report summarizes the events of the 1st International Functional Metagenomics Workshop. The workshop was held on May 7 and 8 in St. Jacobs, Ontario, Canada and was focused on building a core international functional metagenomics community, exploring
Ashby, Deborah, Brady, Sean F., Charles, Trevor, Cowan, Don A., Doemer, John, Edwards, E. A., Engel, Katja, Fiebig, Klaus, Liles, Mark R., Martens, Eric C., McCormac, Dennis, Mead, David A., Miyazaki, Kentaro, Moreno-Hagelsieb, Gabriel, Neufeld, Josh D., O’Gara, F., Reid, A., Rose, David R., Sessitsch, Angela, Simonet, Pascal, Sjöling, Sara, Smalla, K., Streit, Wolfgang R., Tedman-Jones, Jennifer, Valla, Svein, Wellington, E. M. H., Wu, Cheng-Cang   +26 more
core   +7 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

La participación de las personas trans en la actividad física y el deporte: barreras y facilitadores

Arxius de Ciències Socials
Las personas trans son uno de los colectivos más vulnerados en nuestra sociedad. A pesar de los beneficios fisiológicos y psicosociales que puede reportar la práctica de actividad física y deporte (AFD), las personas trans presentan niveles de práctica ...
Elena López-Cañada
doaj   +1 more source