Results 71 to 80 of about 2,773,240 (340)
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
La résistance aux antituberculeux au Canada : 2018
Canada Communicable Disease Report, 2020 Introduction : La tuberculose pharmaco-résistante est une question de santé publique d’importance mondiale constituant une menace contre les efforts entrepris pour lutter contre la tuberculose. Le Canada effectue une surveillance l’échelle nationale pour
Marie LaFreniere +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Longitudinal trends and risk factors for depressed mood among Canadian adults during the first wave of COVID-19 [PDF]
, 2021 Gustavo S. Betini +5 more
openalex +1 more source
HIV in Canada-Surveillance Report, 2018.
Canada communicable disease report = Releve des maladies transmissibles au Canada, 2019 Background Human immunodeficiency virus (HIV) is a global public health issue, with an estimated 36.9 million people living with HIV in 2017. HIV has been reportable in Canada since 1985 and the Public Health Agency of Canada (PHAC) continues to monitor ...
N. Haddad +5 more
semanticscholar +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
A Tale of Two Countries: Cash Demand in Canada and Sweden
, 2021 Walter Engert +2 more
openalex +2 more sources
The Impact of Inflammatory Bowel Disease in Canada 2018: Epidemiology
Journal of the Canadian Association of Gastroenterology, 2018 Canada has among the highest incidence and prevalence of inflammatory bowel disease (IBD) in the world. After decades of rising incidence of IBD in Canada during the 20th Century, the prevalence of IBD in 2018 is 0.7% of the Canadian population ...
G. Kaplan +8 more
semanticscholar +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
SARS Control and Psychological Effects of Quarantine, Toronto, Canada
Emerging Infectious Diseases, 2005 To the Editor: Hawryluck et al. (1) have published an interesting study that found that some persons subject to quarantine for severe acute respiratory distress syndrome (SARS) displayed symptoms of posttraumatic stress disorder and depression.
H. Hull
semanticscholar +1 more source