Results 71 to 80 of about 5,102,780 (337)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The Canada Day Theorem [PDF]

open access: yes, 2012
The Canada Day Theorem is an identity involving sums of $k \times k$ minors of an arbitrary $n \times n$ symmetric matrix. It was discovered as a by-product of the work on so-called peakon solutions of an integrable nonlinear partial differential ...
Gomez, Daniel   +2 more
core  

Review of Czech Refugees in Cold War Canada by Jan Raska [PDF]

open access: yes, 2020
Review of Czech Refugees in Cold War Canada by Jan ...
Falconer, Thirstan
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Advantages and Disadvantages of Signing a Comprehensive Economic and Trade Agreement (CETA) for the Еconomies of the EU and Canada

open access: yesМир новой экономики, 2019
This article presents an analysis of the main provisions of the Comprehensive Economic and Trade Agreement (CETA) signed by the government of Canada and the European Parliament at the end of 2016.
P. Yu. Baryshnikov
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Reconsidering: The Church\u27s Constitution [PDF]

open access: yes, 1995
Evangelical Lutheran Church in ...
Hordern, William Edward
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

The Approach to Seasonal Unemployment in the Nordic Countries: A Comparison with Canada [PDF]

open access: yes
This paper compares policies with respect to seasonal unemployment in the five Nordic countries with Canada. A key finding of this study is that unlike Canada Nordic countries do notspecifically address seasonal employment.
Grady, Patrick, Kapsalis, Constantine
core   +1 more source

High-Potential Employees in the Pipeline: Maximizing the Talent Pool in Canadian Organizations [PDF]

open access: yes, 2013
This report is based on data from 1,574 high-potential employees in Canada. Research suggests that although Canada has seen progress in the experiences of women in the workforce, there is still much room for improvement -- and this improvement is a ...
Anna Beninger
core  

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