Results 41 to 50 of about 10,799 (115)

Progression-Free Survival Under Immune Checkpoint Inhibitors for Metastatic Non-Small-Cell Lung Cancer: A Retrospective Cohort Study

Oncology and Therapy
Introduction Immune checkpoint inhibitors (ICI) are the standard of care for non-small-cell lung cancer (NSCLC) regardless of program death ligand-1 (PDL1) expression.
Paul Boré, Margaux Geier, Loïc Campion, Jean-Luc Raoul, Ludovic Doucet, Sandrine Hiret, Frédéric Bigot, François Bocquet, Laura Mezquita, Teresa Gorria, Judith Raimbourg   +10 more
doaj   +1 more source

Anatomy-based correction of kidney PVE on $$^{177}\text{Lu}$$ 177 Lu SPECT images

EJNMMI Physics
Background In peptide receptor radionuclide therapy (PRRT), accurate quantification of kidney activity on post-treatment SPECT images paves the way for patient-specific treatment.
Julien Salvadori, Oreste Allegrini, Thomas Opsommer, Josefina Carullo, David Sarrut, Clemence Porot, Florian Ritzenthaler, Philippe Meyer, Izzie-Jacques Namer   +8 more
doaj   +1 more source

Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Nature Communications, 2022
Different mechanisms have been reported to explain resistance to chemotherapy in cancer. Here, the authors show that the chemotherapeutic drug 5-fluorouracil alters the function of ribosomes to promote pro-survival gene translation leading to ...
Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C. Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez, Jean-Jacques Diaz   +31 more
doaj   +1 more source

Contemporary Treatment and Survival Outcomes in Mantle Cell Lymphoma: A National Real‐World Analysis From REALYSA, a LYSA Cohort

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Although clinical trials showed outcomes improvement in MCL, their applicability to real‐world practice remains limited. Using the prospective REALYSA registry (NCT03869619), we evaluated contemporary management, highlighting evolving practices and differences by age. Among 295 patients, 63% were ≥ 65 years, 48% had a high‐risk MIPI score with
Morgane Cheminant, Patrick Fogarty, Sylvain Carras, Clémentine Sarkozy, Cédric Rossi, Luc Fornecker, Bijou Fontanet, Adrien Chauchet, Sandra Leguyader‐Peyrou, Laure Lebras, Lucie Oberic, Loïc Ysebaert, Ghandi Damaj, Gaelle Labouré, Ludovic Fouillet, Stéphanie Guidez, François Lemonnier, Krimo Bouabdallah, Thomas Gastinne, Nadine Morineau, Sandy Amorim, Fabrice Jardin, Julie Abraham, Roch Houot, Catherine Thieblemont, Franck Morschhauser, Rémy Gressin, Steven Le Gouill, Olivier Hermine, Fanny Cherblanc, Alain Monnereau, Aurélien Belot, Hervé Ghesquieres, Benoit Tessoulin   +33 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, Volume 20, Issue 8, Page 1905-1912, August 2026.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Dosimetric and clinical validation of a high‐density bolus for superficial skin tumors treated with radiotherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background Accurate dose deposition in superficial radiotherapy remains challenging due to the inherent skin‐sparing effect of megavoltage photon beams and difficulties in ensuring bolus conformity. Purpose This study aims to comprehensively evaluate the dosimetric characteristics of the room‐temperature‐malleable high‐density bolus, to ...
Jonathan Dadoun, Ann Van Esch, Noemie Litrowski, Carine Lefrancois‐Clement, Erwan Luce, Alexis Thelie, Nassima Delhoumi, Andrea Feuillet, Nesrine Zemman, Romain Mallet, Renata Pereira, Laurent Martin, Paul Gangloff, Christophe Moure, Luc Ollivier, Paul Lesueur   +15 more
wiley   +1 more source

RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells

Molecular Oncology
The transcription factor receptor‐interacting protein 140 (RIP140) regulates intestinal homeostasis and tumorigenesis through Wnt signaling. In this study, we investigated its effect on the Notch/HES1 signaling pathway.
Nour Sfeir, Marilyn Kajdan, Stéphan Jalaguier, Sandrine Bonnet, Catherine Teyssier, Samuel Pyrdziak, Rong Yuan, Emilie Bousquet, Antonio Maraver, Florence Bernex, Nelly Pirot, Florence Boissière‐Michot, Audrey Castet‐Nicolas, Marion Lapierre, Vincent Cavaillès   +14 more
doaj   +1 more source

Targeting Human Protein Kinase CK2 by a Library of Indeno[1,2‐b]Indoles: Contribution of Thermal Shift Assay to Pre‐Screening and Co‐Crystallization to Post‐Screening

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
A series of 25 functionalized indeno[1,2‐b]indoles was selected from in‐house compound library and additional synthesis work. Capillary electrophoresis‐based and thermal shift assays, X‐ray analysis of small molecules, and co‐crystallization studies highlighted a key molecular template for the inhibitory potential of protein kinase CK2.
Matheus M. Guimarães, Christian Werner, Belen Leroy, Johana Charles, Jean Guillon, Noël Pinaud, Angélique Mularoni, Marc Jean‐Baptiste, Perrine Ximenes, Alexander Gast, Helge Prinz, Dagmar Aichele, Alan G. Gonçalves, Christelle Marminon, Zouhair Bouaziz, Joachim Jose, Jean‐Guy Delcros, Karsten Niefind, Marc Le Borgne   +18 more
wiley   +1 more source

Issue Information

Cancer Medicine, Volume 15, Issue 10, October 2026.
wiley   +2 more sources

The theranostic: an innovative combination for the diagnosis and therapy of cancers

Journal de la Faculté de Médecine d'Oran, 2022
La recherche en cancérologie doit répondre à un double défi : le diagnostic précoce des tumeurs pour permettre une thérapie efficace et le développement de nouvelles thérapies ciblées. Dans la lutte contre le cancer, les recherches actuelles s’orientent
Nassima MOUSSAOUI
doaj