Results 21 to 30 of about 10,542 (115)

Standard 6-week chemoradiation for elderly patients with newly diagnosed glioblastoma

Scientific Reports, 2021
Glioblastoma (GBM) is frequent in elderly patients, but their frailty provokes debate regarding optimal treatment in general, and the standard 6-week chemoradiation (CRT) in particular, although this is the mainstay for younger patients.
Loïg Vaugier, Loïc Ah-Thiane, Maud Aumont, Emmanuel Jouglar, Mario Campone, Camille Colliard, Ludovic Doucet, Jean-Sébastien Frenel, Carole Gourmelon, Marie Robert, Stéphane-André Martin, Tanguy Riem, Vincent Roualdes, Loïc Campion, Augustin Mervoyer   +14 more
doaj   +1 more source

Annonce de diagnostic en cancérologie : aspects éthiques et déontologiques

Avicenna Medical Research, 2021
introduction: cancer is a complex pathology, most often requiring collaboration from different disciplines and stakeholders The announcement of the cancer diagnosis remains an important step that crystallizes multiple strong issues.
MASSINISSA BENYAGOUB, GACEM OURIDA
doaj   +1 more source

An R package for generic modular response analysis and its application to estrogen and retinoic acid receptor crosstalk

Scientific Reports, 2021
Modular response analysis (MRA) is a widely used inference technique developed to uncover directions and strengths of connections in molecular networks under a steady-state condition by means of perturbation experiments.
Gabriel Jimenez-Dominguez, Patrice Ravel, Stéphan Jalaguier, Vincent Cavaillès, Jacques Colinge   +4 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Une reconnaissance de la singularité en cancérologie

Anthropologie & Santé
This article examines the practices of care personalization through the study of units dedicated to the care of teenagers and young adults with cancer in France (“TYA”, 15-25 years).
Thibaud Pombet
doaj   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Frequency and Factors Associated with Chemotherapy-Induced Peripheral Neuropathies at Donka University Hospital in Conakry [PDF]

Batna Journal of Medical Sciences
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often disabling complication of cancer treatment. Although well documented in high-income countries, data remain scarce in Guinea.
Kalil CISSÉ, Ibrahima Kalil CONDÉ, Ibrahima Alhassane CISSÉ, Arbaba BALDÉ, Bangaly TRAORÉ   +4 more
doaj   +1 more source

Changes in the characteristics of patients treated for brain metastases with repeat stereotactic radiotherapy (SRT): a retrospective study of 184 patients

Radiation Oncology, 2023
Purpose Brain metastases (BMs) are the leading cause of intracranial malignant neoplasms in adults. WHO, Karnofsky performance status (KPS), age, number of BMs, extracerebral progression (ECP), recursive partitioning analysis (RPA), diagnosis-specific ...
L. Kuntz, C. Le Fèvre, D. Jarnet, A. Keller, P. Meyer, A. Thiery, H. Cebula, G. Noel, D. Antoni   +8 more
doaj   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT In a recent publication, Lapitz et al. reported differences in serum levels that predict the development of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis prior to clinical manifestation. We examined whether these biomarkers also predict the risk of gallbladder cancer (GBC) in European prospective plasma samples from ...
Linda Zollner, Jeroen Krijgsveld, Dominique Scherer, Justo Lorenzo Bermejo, on behalf of the EULAT Eradicate GBC Consortium   +4 more
wiley   +1 more source