Results 21 to 30 of about 18,335 (163)

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma? [PDF]

, 2019
Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent.
Badalamenti G., Bazan V., Fanale D., Fulfaro F., Incorvaia L., Iovanna J. L., Olive D., Rinaldi G., Russo A., Swayden M., Terruso L., Vincenzi B.   +11 more
core   +1 more source

Validation of a high performance functional assay for individual radiosensitivity in pediatric oncology: a prospective cohort study (ARPEGE)

BMC Cancer, 2018
Background Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignancies - reach 73.4% thirty years ...
Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner, Guillaume Vogin   +13 more
doaj   +1 more source

Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients

Radiation Oncology, 2023
Background Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure.
L. Kuntz, C. Le Fèvre, D. Jarnet, A. Keller, P. Meyer, A. Thiery, H. Cebula, G. Noel, D. Antoni   +8 more
doaj   +1 more source

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma [PDF]

, 2018
In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated ...
Bintz, Jennifer, Fanale, Daniele, Gayet, Odile, Iovanna, Juan Lucio, Molejon, Maria Ines, Soubeyran, Philippe, Swayden, Mirna   +6 more
core   +1 more source

Standard 6-week chemoradiation for elderly patients with newly diagnosed glioblastoma

Scientific Reports, 2021
Glioblastoma (GBM) is frequent in elderly patients, but their frailty provokes debate regarding optimal treatment in general, and the standard 6-week chemoradiation (CRT) in particular, although this is the mainstay for younger patients.
Loïg Vaugier, Loïc Ah-Thiane, Maud Aumont, Emmanuel Jouglar, Mario Campone, Camille Colliard, Ludovic Doucet, Jean-Sébastien Frenel, Carole Gourmelon, Marie Robert, Stéphane-André Martin, Tanguy Riem, Vincent Roualdes, Loïc Campion, Augustin Mervoyer   +14 more
doaj   +1 more source

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α [PDF]

, 2007
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these pathways.
Jager, S., Handschin, C., St-Pierre, J., Spiegelman, B. M.   +3 more
core   +2 more sources

An R package for generic modular response analysis and its application to estrogen and retinoic acid receptor crosstalk

Scientific Reports, 2021
Modular response analysis (MRA) is a widely used inference technique developed to uncover directions and strengths of connections in molecular networks under a steady-state condition by means of perturbation experiments.
Gabriel Jimenez-Dominguez, Patrice Ravel, Stéphan Jalaguier, Vincent Cavaillès, Jacques Colinge   +4 more
doaj   +1 more source

Annonce de diagnostic en cancérologie : aspects éthiques et déontologiques

Avicenna Medical Research, 2021
introduction: cancer is a complex pathology, most often requiring collaboration from different disciplines and stakeholders The announcement of the cancer diagnosis remains an important step that crystallizes multiple strong issues.
MASSINISSA BENYAGOUB, GACEM OURIDA
doaj   +1 more source

La guérison en cancérologie : une improbable ambition

Saúde e Sociedade
Résumé Cet article propose une réflexion sur la notion de guérison et sur ses usages en cancérologie. Un premier point ausculte sa mise en œuvre en tant qu’ambition à la fois médicale et politique suprême de la mission fondatrice de la cancérologie ...
Marie Ménoret
doaj   +1 more source

Changes in the characteristics of patients treated for brain metastases with repeat stereotactic radiotherapy (SRT): a retrospective study of 184 patients

Radiation Oncology, 2023
Purpose Brain metastases (BMs) are the leading cause of intracranial malignant neoplasms in adults. WHO, Karnofsky performance status (KPS), age, number of BMs, extracerebral progression (ECP), recursive partitioning analysis (RPA), diagnosis-specific ...
L. Kuntz, C. Le Fèvre, D. Jarnet, A. Keller, P. Meyer, A. Thiery, H. Cebula, G. Noel, D. Antoni   +8 more
doaj   +1 more source