Results 11 to 20 of about 18,335 (163)

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines

Scientific Reports, 2023
Pancreatic cancer is one of the most aggressive diseases with a very poor outcome. Olaparib, a PARP inhibitor, as maintenance therapy showed benefits in patients with metastatic pancreatic adenocarcinoma bearing germline BRCA1/2 mutations.
Andréa Witz, Julie Dardare, Aurélie Francois, Marie Husson, Marie Rouyer, Jessica Demange, Jean-Louis Merlin, Pauline Gilson, Alexandre Harlé   +8 more
doaj   +1 more source

Influence of pneumatic transportation on the stability of monoclonal antibodies

Scientific Reports, 2023
Pneumatic transportation systems (PTS) were recently proposed as a method to carry ready-for-injection diluted monoclonal antibodies (mAbs) from the pharmacy to the bedside of patients.
Pierre Coliat, Stéphane Erb, Hélène Diemer, Dan Karouby, Tristan Martin, Mainak Banerjee, Chen Zhu, Martin Demarchi, Sarah Cianférani, Alexandre Detappe, Xavier Pivot   +10 more
doaj   +1 more source

177Lu-DOTA-0-Tyr3-octreotate infusion modeling for real-time detection and characterization of extravasation during PRRT

EJNMMI Physics, 2022
Purpose Given the recent and rapid development of peptide receptor radionuclide therapy (PRRT), increasing emphasis should be placed on the early identification and quantification of therapeutic radiopharmaceutical (thRPM) extravasation during ...
Christophe Mazzara, Julien Salvadori, Florian Ritzenthaler, Simon Martin, Clémence Porot, Alessio Imperiale   +5 more
doaj   +1 more source

[Decision process in oncology: the importance of multidisciplinary meeting] [PDF]

, 2010
International audienceMultidisciplinary meeting (MDM) in oncology has been institutionalised in France by the Cancer Plan. This study aims to determine the place of MDM in the decision process.
Chapet, Sophie, Dorval, Etienne, Duchange, Nathalie, Hervé, Christian, Lemarié, Etienne, Moutel, Grégoire, Orgerie, Marie-Brigitte, Pélicier, Nicole, Rosset, Philippe   +8 more
core   +3 more sources

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Journal of Medical Case Reports, 2023
Background Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multimetastatic disease. Few case reports have suggested solitary digital metastasis as the single secondary lesion of oligometastatic non-small cell ...
Alexandra-Ioana Pușcașu, Fabien Moinard-Butot, Delphine Antoni, Roland Schott, Laura Somme   +4 more
doaj   +1 more source

Longitudinal CITE-Seq profiling of chronic lymphocytic leukemia during ibrutinib treatment: evolution of leukemic and immune cells at relapse

Biomarker Research, 2020
Background Ibrutinib, an irreversible Bruton Tyrosine Kinase (BTK) inhibitor, has revolutionized Chronic Lymphocytic Leukemia (CLL) treatment, but resistances to ibrutinib have emerged, whether related or not to BTK mutations.
Sarah Cadot, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert, Anne Quillet-Mary   +8 more
doaj   +1 more source

Lung stereotactic body radiation therapy: personalized PTV margins according to tumor location and number of four-dimensional CT scans

Radiation Oncology, 2022
Objectives To characterise the motion of pulmonary tumours during stereotactic body radiation therapy (SBRT) and to evaluate different margins when creating the planning target volume (PTV) on a single 4D CT scan (4DCT).
Pierre Trémolières, Ana Gonzalez-Moya, Amaury Paumier, Martine Mege, Julien Blanchecotte, Christelle Theotime, Damien Autret, Stéphane Dufreneix   +7 more
doaj   +1 more source

Selumetinib as an Effective Therapy of Histiocytic Sarcoma Evolving From a B-Cell Acute Lymphoblastic Leukaemia. [PDF]

EJHaem
ABSTRACT Introduction Histiocytic sarcoma (HS) is a rare neoplasm derived from non‐Langerhans histiocytic cells, exceptionally arising from B‐ALL. Methods We present the case of a child with high‐risk B‐ALL with PAX5 P80R mutation. Results Despite initial remission, a chemoresistant paravertebral mass was identified as HS.
Largeaud L, Syrykh C, Vial J, Canali A, Luquet I, Vergez F, Dufrechou S, Prade N, Baruchel A, Gerby B, Nolla M, Delabesse E, Pasquet M.   +12 more
europepmc   +2 more sources

Adjuvant radiation therapy for malignant Abrikossoff’s tumor: a case report about a femoral triangle localisation

Radiation Oncology, 2018
Background Granular cell or Abrikossoff’s tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional.
C. Marchand Crety, C. Garbar, G. Madelis, F. Guillemin, P. Soibinet Oudot, J. C. Eymard, S. Servagi Vernat   +6 more
doaj   +1 more source

Les indicateurs qualité et l'intégration bureaucratique de l'hôpital [PDF]

, 2014
L’hôpital a traditionnellement bénéficié d’une certaine autonomie organisationnelle, qui résultait de la conjonction de l’autonomie des professionnels de santé et de logiques politiques territoriales (Moisdon & Tonneau, 1996).
Benamouzig, Daniel, Robelet, Magali
core   +4 more sources