Results 31 to 40 of about 10,799 (115)

Changes in the characteristics of patients treated for brain metastases with repeat stereotactic radiotherapy (SRT): a retrospective study of 184 patients

open access: yesRadiation Oncology, 2023
Purpose Brain metastases (BMs) are the leading cause of intracranial malignant neoplasms in adults. WHO, Karnofsky performance status (KPS), age, number of BMs, extracerebral progression (ECP), recursive partitioning analysis (RPA), diagnosis-specific ...
L. Kuntz   +8 more
doaj   +1 more source

Lanreotide, a Somatostatin Analogue, in Advanced Merkel Cell Carcinoma: A Prospective Single‐Arm Phase II Study

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine and epithelial skin cancer. Somatostatin analogues, such as lanreotide, have shown efficacy in managing other neuroendocrine tumors. Retrospective studies suggest that lanreotide may induce partial response or disease stabilization in patients with advanced MCC.
Julie Charles   +23 more
wiley   +1 more source

Seeded‐Growth of ZIF‐8 onto Magnetic Nanoparticles: Smart Nanocarriers with Ultrahigh Drug Loading for AMF‐Triggered Release

open access: yesSmall, Volume 22, Issue 55, 1 October 2026.
We developed core‐shell iron oxide@ZIF‐8 magnetic‐MOF nanohybrids via a seeded growth method for magnetic hyperthermia‐triggered drug delivery. Cubic cores and thinner shells maximized heating. In‐situ doxorubicin encapsulation achieved 98% loading, better than surface encapsulation. Polymer coating improved stability.
Ana Maria Panaite   +11 more
wiley   +1 more source

Outcomes of Kaposi sarcoma in people living with HIV who maintain long‐term viral suppression: A prospective case‐series

open access: yesHIV Medicine, Volume 27, Issue 10, Page 1715-1721, October 2026.
Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart   +10 more
wiley   +1 more source

In Pancreatic Carcinoma, Dual EGFR/HER2 Targeting with Cetuximab/Trastuzumab Is More Effective than Treatment with Trastuzumab/Erlotinib or Lapatinib Alone: Implication of Receptors' Down-regulation and Dimers' Disruption

open access: yesNeoplasia: An International Journal for Oncology Research, 2012
We previously demonstrated the synergistic therapeutic effect of the cetuximab (anti-epidermal growth factor receptor [EGFR] monoclonal antibody, mAb)-trastuzumab (anti-HER2 mAb) combination (2mAbs therapy) in HER2low human pancreatic carcinoma ...
Christel Larbouret   +9 more
doaj   +1 more source

Controversies in NEN: An ENETS position statement on the role of liver transplantation (LT) in patients with advanced small‐intestinal and pancreatic NETs

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Liver transplantation (LT) may offer survival or symptomatic benefit for highly selected patients with advanced, well‐differentiated small‐intestinal or pancreatic neuroendocrine tumours and unresectable liver‐dominant metastases. However, its role remains controversial, as LT is rarely curative, recurrence is common, and benefits must be ...
Peter Stålberg   +11 more
wiley   +1 more source

Fertility sparing surgery for ovarian sex cord stromal tumors: a nine case series

open access: yesThe Pan African Medical Journal, 2018
Ovarian Sex Cord Stromal Tumors (SCST) are a rare disease carrying a good prognosis. They generally affect young women; therefore fertility preservation is a critical issue.
Montassar Ghalleb   +6 more
doaj   +1 more source

New Observations on a Low‐Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type

open access: yesNeuropathology and Applied Neurobiology, Volume 52, Issue 5, October 2026.
Two new cases of low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1 mutant, are described in an 18‐year‐old and a 50‐year‐old male, both with supratentorial lesions, characteristic rhabdoid histology on a myxoid‐collagenous background, and complete INI1 loss.
Alice Métais   +13 more
wiley   +1 more source

Not just splitting hairs—monitoring environmental chemical exposures, their biological effects and their social determinants with hair shafts and follicles: a narrative review

open access: yesEnvironmental Health
Humans encounter a wide range of natural and synthetic chemicals throughout their lifespan and these exposures have a complex impact on health outcomes.
Marie Robert   +6 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud   +12 more
wiley   +1 more source

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