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PRL‐3 phosphatase and cancer metastasis
Journal of Cellular Biochemistry, 2010AbstractThe deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL‐1 and PRL‐3 both possess the capacity to drive key steps in metastatic progression.
Abdul Qader O, Al-Aidaroos, Qi, Zeng
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Role of 3-mercaptopyruvate sulfurtransferase in cancer
Cellular SignallingThe enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is widely distributed across different biological entities and is essential for the production of hydrogen sulfide (H₂S). This enzyme functions both in the cytosol and mitochondria, and 3-MST mediates the reaction of 3-mercaptopyruvate (3-MP) with dihydrolipoic acid and thioredoxin to generate ...
Xue-Li, Wang +9 more
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The phosphoinositide 3-kinase pathway and cancer
Expert Reviews in Molecular Medicine, 2005Human tumours emerge as the result of multiple genetic and epigenetic aberrations that allow the proto-cancer cell to escape normal social control. Many signal transduction pathways become constitutively active during this process, and one whose importance is increasingly being appreciated involves phosphoinositide 3-kinase (PI3-kinase).
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