Results 111 to 120 of about 5,262,481 (310)

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]

, 2012
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J, Kenneth Macleod, Yamaguchi, Azusa, Macleod, Kenneth, Galina Lebedeva, David J Harrison, Lebedeva, Galina, Langdon, Simon P., Langdon, Simon P, Azusa Yamaguchi, Harrison, David J., Simon P Langdon   +11 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Structural biology and cancer [PDF]

BMC Proceedings, 2013
The techniques of structural biology currently play an important role in the development of novel therapeutic agents including cancer chemotherapies. X-ray crystallography has proved to be a particularly powerful tool for both the discovery of novel compounds and their subsequent development.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Gene expression analysis in human breast cancer associated blood vessels [PDF]

, 2012
Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types.
John M J Herbert, Jones, DT, Richard Mitter, John M. J. Herbert (132335), Jones D. T., Bicknell, R, Francesca Buffa, Adrian L. Harris (132344), Li Ji-Liang, Li, J-L, Herbert, JMJ, Mitter Richard, Roy Bicknell (54952), Harris A. L., Buffa F., Buffa, Francesca, Mitter, R, Adrian L Harris, Kairbaan Hodivala-Dilke, J Louise Jones, Tanguy Lechertier, Lechertier Tanguy, Tanguy Lechertier (132331), Herbert, JM, Roy Bicknell, Kairbaan Hodivala-Dilke (132348), Herbert John M. J., Lechertier, T, Harris Adrian L., Lechertier T., Francesca Buffa (132341), Hodivala-Dilke Kairbaan, Mitter R., Hodivala-Dilke, K, Jones J. Louise, Ji-Liang Li (132339), Jones, JL, Harris, AL, Buffa, F, Richard Mitter (132333), Bicknell Roy, Li, JL, Dylan T. Jones (132329), Dylan T Jones, Jones Dylan T., Bicknell R., Ji-Liang Li, Herbert J. M. J., Li J. -L., J. Louise Jones (132337), Buffa Francesca, Jones J. L., Hodivala-Dilke K., et al,   +53 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cancer Trends: Cancers of the head and neck

, 2014
Cancers of the head and neck (H&N) are a heterogeneous group, consisting of cancers of the mouth (base of tongue, other tongue, gum, floor of mouth, palate and other mouth; ICD 10 codes C01–C06); salivary glands (C07–C08); pharynx (tonsil, oropharynx,
National Cancer Registry Ireland (NCRI)
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Cancer Trends: non-Hodgkin’s lymphoma (NHL)

, 2013
An average of 660 cases of non Hodgkin’s lymphoma (NHL) was diagnosed per year in Ireland between 2007 and 2011 (Table 1). Incidence rates were slightly higher in males than in females where NHL was the 5th and 8th most common cancer diagnosed ...
National Cancer Registry Ireland (NCRI)
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source