Results 41 to 50 of about 5,262,481 (310)

Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

eLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between ...
Irawati Kandela, Hyun Yong Jin, Katherine Owen, Reproducibility Project: Cancer Biology   +3 more
doaj   +1 more source

THE BIOLOGY OF BREAST CANCER

Hematology/Oncology Clinics of North America, 1999
This article focuses on the major hormones and growth factors for which a critical role in normal mammary growth has been clearly defined. Certainly other hormonal systems and growth factors could also affect breast cancer initiation and progression, but their exact contribution to normal and/or malignant breast cell growth is poorly delineated ...
S J, Nass, N E, Davidson
openaire   +2 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Aquaporins in Cancer Biology

Frontiers in Oncology, 2022
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were initially characterized as a novel protein family that plays a vital role in transcellular and transepithelial water movement. AQP1, AQP2, AQP4, AQP5, and AQP8 are primarily water selective, whereas AQP3, AQP7, AQP9, and AQP10 (called “aqua-glyceroporins”) also transport
Chul So Moon, Chul So Moon, David Moon, David Moon, Sung Koo Kang, Sung Koo Kang   +5 more
openaire   +3 more sources

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State

, 2020
Cancer stem cells (CSCs) are located in dedicated niches, where they remain inert to chemotherapeutic drugs and drive metastasis. Although plasticity in the CSC pool is well appreciated, the molecular mechanisms implicated in the regulation of cancer ...
Blanas, Athanasios, de Kok, Mike, J van Vliet, Sandra, Laura Kruijssen, Marko A. Popovic, Sandra J. van Vliet, Athanasios Blanas, van der Haar Àvila, Irene, Zaal, Anouk, van der Horst, Joost C, Popovic, Marko A, Irene van der Haar Àvila, Anouk Zaal, Mike de Kok, Kempers, Maxime, Kruijssen, Laura, Maxime Kempers, Joost C. van der Horst   +17 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Registered report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Vidhu Sharma, Lisa Young, Miguel Cavadas, Kate Owen, Reproducibility Project: Cancer Biology   +4 more
doaj   +1 more source

Lysosomal Biology in Cancer [PDF]

, 2017
Cells depend on the lysosome for sequestration and degradation of macromolecules in order to maintain metabolic homeostasis. These membrane-enclosed organelles can receive intracellular and extracellular cargo through endocytosis, phagocytosis, and autophagy.
Colin, Fennelly, Ravi K, Amaravadi
openaire   +2 more sources

Emerging evidence for CHFR as a cancer biomarker : from tumor biology to precision medicine [PDF]

, 2013
Novel insights in the biology of cancer have switched the paradigm of a "one-size-fits-all" cancer treatment to an individualized biology-driven treatment approach.
Brandes, Johann C, Brandes, Johann C., Herman, James G., Derks, S., Kim M. Smits, de Bruine, Adriaan P., Nilofer Azad, Smits, K.M., Cleven, Arjen H. G., Azad, N., Manon van Engeland, Van Criekinge, WimLA268010009727840000-0003-2971-5539F4D5440C-F0ED-11E1-A9DE-61C894A0A6B4, Johann C. Brandes, Smits, Kim M., Cleven, A.H.G., Cleven, Arjen HG, James G. Herman, Melotte, Veerle, van Engeland, Manon, Arjen H. G. Cleven, Veerle Melotte, de Bruïne, Adriaan P, van Engeland, M., Azad, Nilofer, Herman, James G, Wim van Criekinge, Herman, J.G., Adriaan P. de Bruïne, Brandes, J.C., Sarah Derks, Derks, Sarah, Van Criekinge, Wim, de Bruine, A.P., Smits, Kim M, Melotte, V., Van Criekinge, W.   +35 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source