Results 101 to 110 of about 61,183 (295)

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy

Pharmacological Research
Cancer cachexia, a multifactorial metabolic syndrome impacts 50–80 % cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 ...
Ruiqin Zhang, Nan Li, Ke Yu, Qiongsen Wang, Meng Fan, Xiongwen Zhang, Xuan Liu   +6 more
doaj   +1 more source

Living in interesting times - Challenging protein metabolism in the era of the epidemiological shift [PDF]

, 2016
The recently released results of the Global Burden of Disease, Injuries, and Risk Factor study 2013 reveal that during the past 23 years, metabolic and behavioral risk factors, including high BMI, increased their impact on global mortality and disability-
Laviano, Alessandro
core   +1 more source

PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells

Advanced Materials, EarlyView.
Detecting proteins secreted by a single cell while retaining its viability remains challenging. A particles‐in‐particle (PiPs) system made by co‐encapsulating barcoded microparticles (BMPs) with a single cell inside an alginate hydrogel particle is introduced.
Félix Lussier, Byeong‐Ui Moon, Mojra Janta‐Polczynski, Yonatan Morocz, Fabian Svahn, Molly Shen, Ljuboje Lukic, Lidija Malic, Teodor Veres, Andy Ng, David Juncker   +10 more
wiley   +1 more source

Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice [PDF]

, 2018
BACKGROUND: Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by
Alter, Aulino, Ben-David, Bilir, Bonetto, Bonetto, Cornwell, Delitto, Delitto, Dingemans, Fearon, Fearon, Fukawa, Gascan, Graf, Haehling, He, Iseki, Jackman, Jo, Johns, Judge, Kir, Lerner, Loumaye, Martin, Mori, Mori, Onesti, Penna, Petruzzelli, Rubin, Sagar, Schafer, Seto, Stephens, Talbert, Tseng, Villiger, Zhang   +39 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article

Caspian Journal of Internal Medicine, 2021
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life.
Noorwati Sutandyo
doaj  

The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis [PDF]

, 2017
Background A body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic validity, evaluating its ...
Bauer, Blum, Blum, Dewys, Fearon, Fearon, Groenvold, Haehling, Haugstvedt, Hinsley, Hjermstad, Katz, Martin, McClement, Millar, Osoba, Prado, Ross, Sanders, Schag, Solheim, Tisdale   +21 more
core   +4 more sources

Recent Advances in Collective Behaviors of Micro/Nanomotor Swarms

Advanced Materials, EarlyView.
This review describes the driving forces behind collective motion, explores the self‐organization of micro/nano swarms across zero‐dimensional (0D), one‐dimensional (1D), two‐dimensional (2D), and three‐dimensional (3D) spaces, and highlights their potential in drug delivery, environmental monitoring, and smart devices.
Siwen Sun, Bingbing Sun, Alexander B. Cook, Tania Patiño Padial, Jan C. M. van Hest   +4 more
wiley   +1 more source

Comparison of the cachexia index based on hand-grip strength (H-CXI) with the original CXI for the prediction of cancer cachexia and prognosis in patients who underwent radical colectomy for colorectal cancer

Frontiers in Nutrition
Background and aimsThe cachexia index (CXI) is a novel biomarker for estimating cancer cachexia. The cachexia index based on hand-grip strength (H-CXI) has been recently developed as a simple proxy for CXI.
Xia-Lin Yan, Lian-Ming Wu, Xiu-Bo Tang, Zong-Ze Li, Zhao Zhang, Hao-Jie Jiang, Zhang-Tao Chen, Ding-Hao Chen, Jiang-Yuan Li, Xian Shen, Dong-Dong Huang   +10 more
doaj   +1 more source

Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials

BMC Cancer, 2018
Background Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline.
Shailesh M. Advani, Pragati G. Advani, Helena M. VonVille, Syed H. Jafri   +3 more
doaj   +1 more source