Results 91 to 100 of about 3,014,693 (296)

A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain

Journal of Pharmacological Sciences, 2019
Cancer cachexia is a systemic wasting syndrome characterized by anorexia and loss of body weight. The xanthine oxidase (XO) inhibitor febuxostat is one of the promising candidates for cancer cachexia treatment.
Miaki Uzu, Miki Nonaka, Kanako Miyano, Hiromi Sato, Nagomi Kurebayashi, Kazuyoshi Yanagihara, Takashi Sakurai, Akihiro Hisaka, Yasuhito Uezono   +8 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Selective activation of the unfolded protein response and proteolytic pathways in sarcopenic limb muscles of bronchiectasis patients

ERJ Open Research
Introduction Sarcopenia contributes significantly to decreased exercise tolerance, reduced quality of life and worse overall prognosis, independent of lung function severity in chronic respiratory disease including bronchiectasis.
Adriana Núñez-Robainas, Alberto Solano, Salvatore Marsico, Mariela Alvarado-Miranda, Maria Cinta Cumpli-Gargallo, Marina Sáinz-Hernández, José María Maiques, Esther Barreiro   +7 more
doaj   +1 more source

Targeted prevention of skeletal muscle wasting in cancer cachexia with combinatorial RNAi-based approaches [PDF]

openCancer cachexia is a wasting syndrome responsible for systemic multi-factorial metabolic dysfunctions leading to severe body weight loss due to excessive muscle and adipose tissue catabolism.
BERBER, ASUDE
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia

Current Issues in Molecular Biology
Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remain elusive ...
Takuya Hasegawa, Kohichi Kawahara, Koji Sato, Yoshihisa Asano, Takehiko Maeda   +4 more
doaj   +1 more source

InACTIVatINg cancer cachexia [PDF]

Disease Models & Mechanisms, 2011
Summary of and comment on a recent Cell paper entitled ‘Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival’ (Zhou et al., 2010).
openaire   +3 more sources

Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series. [PDF]

BACKGROUND: In patients receiving anti-cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no systematic review of oncological endpoints in cancer cachexia (CC) trials.
Brown, LR, Vagnildhaug, OM, Laird, BJA, Simpson, M, Bye, A, Dolan, R, Hjermstad, M, Solheim, TS, Arends, J, Philips, I, Ottestad, I, Jakobsen, G, Størkson, EK, Sayers, J, Dajani, O, Sousa, MS, Stares, M, Skipworth, RJE, Balstad, TR, Kaasa, S, Greil, C, McDonald, J, Cancer Cachexia Endpoints Working Group,, Yule, MS   +23 more
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source