Results 101 to 110 of about 3,014,693 (296)

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy

Pharmacological Research
Cancer cachexia, a multifactorial metabolic syndrome impacts 50–80 % cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 ...
Ruiqin Zhang, Nan Li, Ke Yu, Qiongsen Wang, Meng Fan, Xiongwen Zhang, Xuan Liu   +6 more
doaj   +1 more source

Cachexia in cancer

Journal of British Surgery, 1984
H A F Dudley, R I C Wesdorp, R Krause, M F Von Meyenfeldt   +3 more
openaire   +4 more sources

The Bromodomain inhibitor JQ1 prevents skeletal muscle loss during cancer cachexia

, 2015
Skeletal muscle wasting is a hallmark of cancer cachexia. This metabolic syndrome is responsible for about 25% of cancer deaths. In particular, muscle loss in cachectic patients often leads to increased morbidity and mortality, decreased beneficial ...
G. Caretti, M. Segatto, Segatto, M., P. Costelli, R. Fittipaldi   +4 more
core  

Nutritional Interventions for Cancer-Induced Cachexia

, 2011
Cancer-induced cachexia remains a significant cause of morbidity and mortality in cancer treatment. Cancer research and development continues at an aggressive pace and yet a degree of cancer-induced cachexia is experienced by up to 80% of advanced stage ...
Mazurak, Vera, Gullett, Norleena P., Vera C. Mazurak, Hebbar, Gautam, Gautam Hebbar, Norleena P. Gullett, Thomas R. Ziegler, Ziegler, Thomas R.   +7 more
core   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Cardiac wasting is not cardiac cachexia: the problem of the subjective/objective genitive in matters of the heart

European Journal of Translational Myology
Tessitore, Costelli et al. were among the first to report a previously unnoticed loss of heart mass in cachectic mice suffering from a severe tumor burden.
Anna Luisa Mazzotti, Medhi Hassani, Zhenlin Li, Denise Paulin, Onnik Agbulut, Dario Coletti   +5 more
doaj   +1 more source

The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article

Caspian Journal of Internal Medicine, 2021
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life.
Noorwati Sutandyo
doaj  

Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials

BMC Cancer, 2018
Background Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline.
Shailesh M. Advani, Pragati G. Advani, Helena M. VonVille, Syed H. Jafri   +3 more
doaj   +1 more source

Monitoring Metastasis and Cachexia in a Patient with Breast Cancer: A Case Study

, 2016
Cachexia, a wasting syndrome associated with advanced cancer and metastasis, is rarely documented in breast cancer patients. However, the incidence of cachexia in breast cancer is now thought to be largely underestimated.
Binsheng Zhao, Swarnali Acharyya, Hanina Hibshoosh, Xiaotao Guo, Kevin Kalinsky, Courtney Coker, Sara Lopez-Pintado, Nikita Consul   +7 more
core   +1 more source