Results 71 to 80 of about 8,103,215 (300)

Addressing cancer care inequities in sub-Saharan Africa: current challenges and proposed solutions

International Journal for Equity in Health, 2023
Introduction Cancer is a significant public health challenge globally, with nearly 2000 lives lost daily in Africa alone. Without adequate measures, mortality rates are likely to increase.
Olabode Omotoso, John Oluwafemi Teibo, Festus Adebayo Atiba, Tolulope Oladimeji, Oluwatomiwa Kehinde Paimo, Farid S. Ataya, Gaber El-Saber Batiha, Athanasios Alexiou   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Predictors of knowledge and attitudes toward palliative care among patients with cancer: a cross-sectional study

Scientific Reports
Palliative care (PC) can help improve the quality of life of patients with cancer. The knowledge and attitudes of cancer patients toward PC play a significant role in the use of PC services.
Maryam Momeni, Soolmaz Moosavi, Sina Pakmehr, Fateme Hasandoost   +3 more
doaj   +1 more source

Understanding the Role of Anaesthesiologists in Cancer Care: A Knowledge, Attitude and Practice Survey amongst Healthcare Workers: A Cross-sectional Study

Journal of Onco-Anaesthesiology and Perioperative Medicine
Background and Aims: Evaluation of the knowledge, attitudes and practices (KAP) of healthcare workers (HCWs) towards anaesthesiology in cancer care is important to analyse the gaps and guide targeted educational curriculum and multidisciplinary ...
Archana Gautam, Ruchi Saxena, Vandna Bharti, Indubala Maurya, Shagufta Ansari, Devesh Kumar Shukla   +5 more
doaj   +1 more source

The barriers to initiating lung cancer care in low-and middle-income countries

The Pan African Medical Journal, 2020
Lung cancer in low-and middle-income countries is the leading and the second leading cause of cancer deaths in males and females, respectively. This, in part, is due to late presentation of patients in health facilities and late diagnosis, thereby ...
Buhle Lubuzo, Themba Ginindza, Khumbulani Hlongwana   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Coordinating under constraint: a qualitative study of communication and teamwork along Ethiopia’s cervical cancer care continuum

BMC Health Services Research
Background As Ethiopia expands cervical cancer screening services, it urgently needs information to develop appropriate post-screening diagnostic and treatment services for women with abnormal results.
Sahai Burrowes, Hanamariam Seyoum Alemu, Natasha Khokhar, Genevive McMillian, Souad Hamade, Roman Dmitriyev, Khoa Pham, Sarah Whitney, Baye Galew, Eiman Mahmoud, Alexandra Lydia Hernandez   +10 more
doaj   +1 more source

Experiences of adult patients with cancer at a specialized cancer care facility in Uganda

Journal of Psychosocial Oncology Research and Practice
Abstract Background: The experiences of adult cancer patients in low-income countries regarding health care and infrastructure are largely undocumented. This study aimed to describe the experiences of adult men and women receiving treatment at a specialized cancer facility in Uganda ...
Allen M. Naamala, Zarina N. Kabir, Jackson Orem, Gorrette K. Nalwadda, Patience A. Muwanguzi, Lena Wettergren   +5 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source