Results 71 to 80 of about 7,685,054 (318)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Associations between quality of life and health literacy in a Norwegian urban cancer population—a cross-sectional study

Health Literacy and Communication Open
Background Cancer presents challenges for patients due to its complexity and treatment demands, resulting in a low quality of life. Patients must manage amounts of information, and make care decisions.
Marit Leine, Astrid K. Wahl, Simen A. Steindal, Åsmund Hermansen, Martha P. Lein, Milada Hagen, Caryl Gay, Kjell Magne Tveit, Christine R. Borge   +8 more
doaj   +1 more source

Patterns of care in pancreatic cancer radiotherapy: impact of facility volume on outcomes

Frontiers in Oncology
Objectives Radiotherapy (RT), particularly stereotactic body radiotherapy (SBRT), is a promising treatment for borderline resectable or locally advanced pancreatic cancer (PC). This study evaluated the association of RT facility volume with overall survival (OS) and examined patterns of care for patients with PC.
Rajan, Arvind, Gleeson, Elizabeth M., Pham, Veronica, Goodman, Karyn A.   +3 more
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Facilitating equity-oriented cancer care in organizations delivering cancer services: insights from a qualitative study

Frontiers in Oncology
BackgroundPeople experiencing structural marginalization often have advanced cancer diagnoses and higher cancer-related mortality resulting, in part, from poor access to care.
Tara C. Horrill, Jess Crawford, Scott M. Beck, Amber Bourgeois, Amber Bourgeois, Jagbir Kaur, Leah K. Lambert, Leah K. Lambert, Michael McKenzie, Kelli I. Stajduhar, Annette J. Browne   +10 more
doaj   +1 more source

Geographic distribution of health services in the breast cancer care pathways in Pernambuco, Northeast of Brazil [PDF]

Revista Brasileira de Saúde Materno Infantil
Objectives: to analyze the geographic distribution of breast cancer care services in Pernambuco, northeastern Brazil. Methods: a descriptive cross-sectional study analyzing the geographic distribution of breast cancer care services, which used the ...
Rosalva Raimundo da Silva, Iris Edná Pereira da Silva, Geyssyka Morganna Soares Guilhermino, Wisley Donizetti Velasco, Isabel Cristina Areia Lopes Pereira, Tereza Maciel Lyra   +5 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Comparison of Knowledge, Attitude, and Practices of Nursing Staff Regarding Cervical Cancer Screening at Various Levels of Health Care Facilities in Western India

Indian Journal of Community Medicine
Background: Cervical cancer is a public health problem, and nursing personnel are crucial for successful implementation of low-cost cervical cancer screening approaches in low-resource settings.
Rashmi Kaushal, Mamta Patel, Pankaj Bhardwaj, Manoj Gupta, Deepti Mathur, Girish Chandra Dash, Shashank Shekhar   +6 more
doaj   +1 more source

Cancer Trends: Cancer of unknown primary

, 2019
Between 2012 and 2016, over 450 patients per year were diagnosed with a malignant cancer where the primary site of their cancer was unspecified. These cancers were identified by the presence of metastatic disease where the cancer has spread to other ...
National Cancer Registry Ireland (NCRI)
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source