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Immunogenic Cell Death in Cancer Therapy
Annual Review of Immunology, 2013Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the cell surface as well as the release of soluble mediators, occurring in a defined temporal sequence. Such signals operate on a series of receptors expressed by dendritic cells to stimulate
Guido, Kroemer +3 more
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2013
Research into the mechanisms and regulation of cell death has not only given insights into how cancers arise but also provided targets for the development of novel treatments. A cancer is a clonally related population of cells that persists, in part, because cells with altered DNA have been able to survive.
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Research into the mechanisms and regulation of cell death has not only given insights into how cancers arise but also provided targets for the development of novel treatments. A cancer is a clonally related population of cells that persists, in part, because cells with altered DNA have been able to survive.
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Oxysterols in cancer cell proliferation and death
Biochemical Pharmacology, 2013Oxysterols have been shown to interfere with proliferation and cause the death of many cancer cell types, such as leukaemia, glioblastoma, colon, breast and prostate cancer cells, while they have little or no effect on senescent cells. The mechanisms by which oxysterols may influence proliferation are manifold: they control the transcription and the ...
Jan, de Weille +2 more
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Programmed Cell Death in Breast Cancer
1995Abstract : E HAVE INITIATED STUDIES OF PROGRAMMED CELL DEATH, OR POPTOSIS, IN HUMAN BREAST CANCER CELLS. Using the MCF-V reast cancer cell line, we have found that cell growth is stimulated by supplementing the culture medium with l%%-estradio1, and inhibited by charcoal stripping serum o remove steroid hormones.
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The role and regulation of cell death in cancer
Regulated cell death (RCD) is an essential aspect of cellular homeostasis and coordinates important physiological processes, such as immune regulation, embryogenesis, and tissue remodeling. In cancer, the regulation of RCD is disrupted to allow tumor cells to resist apoptosis, modify their function to survive microenvironmental stresses, and become ...Minh Trong, Quang +2 more
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