Results 101 to 110 of about 8,124,451 (335)

Cancer Classification at the Crossroads [PDF]

Cancers, 2020
Internationally accepted classifications of malignant tumors, developed by the World Health Organization (WHO) and the Union for International Cancer Control (UICC), are based on the histotype, site of origin, morphologic grade, and spread of cancer throughout the body.
openaire   +2 more sources

Proteomic Classification of Breast Cancer [PDF]

Current Drug Targets, 2012
Being a significant health problem that affects patients in various age groups, breast cancer has been extensively studied to date. Recently, molecular breast cancer classification has advanced significantly with the availability of genomic profiling technologies.
Kamel, Dalia, Brady, Bernadette, Tabchy, Adel, Mills, Gordon B, Hennessy, Bryan   +4 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Utilizing Machine Learning Techniques for Cancer Prediction and Classification based on Gene Expression Data

UHD Journal of Science and Technology
Cancer classification through genetic evaluation has become a hot topic among researchers. It holds the promise of delivering systematic, precise, and scientifically backed diagnoses for different types of cancer. Lately, several studies have delved into
Mariwan Mahmood Hama Aziz, Sozan Abdullah Mahmood   +1 more
doaj   +1 more source

Gene Selection in Cancer Classification Using Sparse Logistic Regression with L1/2 Regularization

Applied Sciences, 2018
In recent years, gene selection for cancer classification based on the expression of a small number of gene biomarkers has been the subject of much research in genetics and molecular biology.
Shengbing Wu, Hongkun Jiang, Haiwei Shen, Ziyi Yang   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cancer Pain Assessment and Classification [PDF]

Cancers, 2019
More than half of patients affected by cancer experience pain of moderate-to-severe intensity, often in multiple sites, and of different etiologies and underlying mechanisms. The heterogeneity of pain mechanisms is expressed with the fluctuating nature of cancer pain intensity and clinical characteristics.
Caraceni A, Shkodra M
openaire   +3 more sources

Using Machine Learning and Natural Language Processing to Review and Classify the Medical Literature on Cancer Susceptibility Genes

, 2019
PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools monitoring and prioritizing the literature to understand the clinical implications of the pathogenic genetic variants.
Acevedo, Francisco, Armengol, Victor Diego, Bao, Yujia, Barzilay, Regina, Braun, Danielle, Deng, Zhengyi, Hughes, Kevin S, Kim, Heeyoon, Ouardaoui, Nofal, Parmigiani, Giovanni, Wang, Cathy, Wang, Yan   +11 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source