Results 111 to 120 of about 5,397,815 (312)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DiagnosticsBackground/Objectives: Cancer classification using microarray datasets presents a significant challenge due to their extremely high dimensionality. This complexity necessitates advanced optimization methods for effective gene selection.
Shahad Alkamli, Hala Alshamlan
doaj +1 more source
Cancer Trends: non-Hodgkin’s lymphoma (NHL)
, 2013 An average of 660 cases of non Hodgkin’s lymphoma (NHL) was diagnosed per year in Ireland between 2007 and 2011 (Table 1). Incidence rates were slightly higher in males than in females where NHL was the 5th and 8th most common cancer diagnosed ...
National Cancer Registry Ireland (NCRI)
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Frontiers in Big DataThis review systematically summarizes recent advances in microarray feature selection techniques and their applications in biomedical research. It addresses the challenges posed by the high dimensionality and noise of microarray data, aiming to integrate
Fangling Wang +9 more
doaj +1 more source
Cancer in Ireland 1994-2019: Annual Report of the National Cancer Registry 2021
, 2021 Highlights this year include: • Five-year net survival averaging 65% for patients diagnosed between 2014 and 2018, a substantial increase from twenty years previously when 42% was the average.
National Cancer Registry Ireland (NCRI)
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Hybrid Gene Selection Algorithm for Cancer Classification Using Nuclear Reaction Optimization (NRO)
Current Issues in Molecular BiologyMicroarray gene expression data are characterized by high dimensionality and small sample sizes, which complicates cancer classification tasks. To address these challenges, this study proposes a hybrid gene selection approach that integrates a filter ...
Shahad Alkamli, Hala Alshamlan
doaj +1 more source
Cancer Trends: HPV-associated cancers
, 2017 Chronic infection with oncogenic (tumour-causing) strains of human papillomavirus (HPV) is now well-established as an important risk factor for anogenital (cervical, vaginal, vulvar, penile and anal/rectal) and head and neck (specifically oropharyngeal ...
National Cancer Registry Ireland (NCRI)
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