Results 141 to 150 of about 5,397,815 (312)

Cancer in Ireland 2013 - annual report of the National Cancer Registry [PDF]

, 2013
This report highlights the continuing increase in the cancer burden in Ireland.
National Cancer Registry Ireland (NCRI)
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cancer in Ireland 1994-2012: Annual Report of the National Cancer Registry

, 2014
In the most recent three years for which full data are available (2010-2012), on average about 36,000 newly diagnosed tumours were registered per year. Of these cases, just over 20,000 involved invasive cancers other than the less serious, non-melanoma ...
National Cancer Registry Ireland (NCRI)
core  

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.

UNLABELLED: Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers.
Sjöström, M, Ning, Y, Witte, ON, Boutros, PC, Huang, FW, Perry, MD, Gleave, M, Zwart, W, Shrestha, R, Phillips, T, Maher, CA, He, HH, Aggarwal, R, Fraser, M, Petricca, J, Small, EJ, Quigley, DA, Bjartell, A, Ye, W, Morgans, AK, Ashworth, A, Maurice-Dror, C, Ng, SWS, Moreno-Rodriguez, T, Haffner, MC, Levy, S, Beer, TM, Gilbert, LA, Zhao, SG, Fong, L, Rettig, MB, Annala, M, Bose, R, He, C, Lloyd, P, Mahajan, NP, Cui, X-L, McCarthy, E, Chou, J, Hua, JT, Evans, CP, Feng, FY, Li, H, Chen, S, Chen, WS, Foye, A, Zoubeidi, A, Chi, KN, Lang, JM, Bergamaschi, A, Chesner, L, Tran, PT, Lundberg, A, Herberts, C, Posadas, EM, Wyatt, AW, Luo, J, Maheshwari, A, Zhang, M, Thomas, GV, Huang, J, Reiter, RE, Alumkal, JJ, Lara, PN   +63 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Cancer care and survival in relation to centralisation of Irish cancer services: an analysis of National Cancer Registry data 1994-2015

, 2019
In this report, data collected by the National Cancer Registry are used to provide descriptive statistics on place of treatment, proportions treated and survival for cancer patients in Ireland from a perspective of ten years following the start of the ...
National Cancer Registry Ireland (NCRI)
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Cancer incidence projections for Ireland 2020-2045

, 2019
The most recent annual statistical report of the National Cancer Registry, published in November 2018, provided a summary of projected changes in the cancer incidence burden in Ireland over the coming decades, up to 2045.
National Cancer Registry Ireland (NCRI)
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source