Results 131 to 140 of about 61,212,533 (299)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

O conhecimento e a prática de mamografia em mulheres residentes em Florianópolis/SC: estudos de base populacional [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2013O objetivo deste trabalho é descrever o conhecimento e a prática de mamografia e identificar os ...
Schneider, Ione Jayce Ceola
core  

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Integralidade do Cuidado à Mulher com Câncer de Mama: Desafios na Implementação da Linha de Cuidado em um Estado do Nordeste do Brasil

Revista Brasileira de Cancerologia
Introdução: O câncer de mama é um problema de saúde pública significativo em razão da alta incidência e mortalidade entre as mulheres. Objetivo: Analisar a integralidade do cuidado à mulher com câncer de mama na Rede de Atenção à Saúde em um Estado do ...
Rosalva Raimundo da Silva, Mauricéa Maria de Santana, Adriana Falangola Benjamin Bezerra, Jurema Telles de Oliveira Lima, Tereza Maciel Lyra   +4 more
doaj   +1 more source

BRCAness and breast cancer: BRCAness y cáncer de mama

, 2021
Breast cancer constitutes the neoplasm of highest incidence, prevalence and mortality among women in western countries. Around 25-30% of these tumors are estrogen receptor (ER), progesterone receptor (PR) and HER2 negative. These tumors are called triple negative breast cancer (TNBC). TNBCs frequently appear in young patients.
openaire   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Análise dos fatores de risco em mulheres com cancer de mama

Brazilian Journal of Development
O câncer de mama e as doenças cardiovasculares possuem amplo impacto na saúde mundial. De etiologia multifatorial, ambas as doenças podem ser desenvolvidas por hábitos de vida não saudáveis, como o uso de tabaco e álcool, sedentarismo, obesidade e diabetes. Além disso, o câncer de mama pode estar associado a fatores genéticos e reprodutivos.
Gabrielle Feu Pereira, Beatriz Rodrigues Fialho, Rodrigo Alves Faria, Lorena Souza Rittiberg Mauricio, Cleide dos Santos Coelho, Maria Teresa Martins de Araújo, Vinícius Mengal, Sonia Alves Gouvea   +7 more
openaire   +1 more source

The Benefits of Exercise in Breast Cancer. [PDF]

Arq Bras Cardiol, 2022
Campos MDSB, Feitosa RHF, Mizzaci CC, Flach MDRTV, Siqueira BJM, Mastrocola LE.   +5 more
europepmc   +1 more source

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing

Arthritis &Rheumatology, Accepted Article.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source