Results 21 to 30 of about 3,425,228 (311)

Cancer Stem Cells: Roles in Cancer Etiology

, 2023
Cancer stem cells (CSCs) are a rare subpopulation of tumor cells with stemness properties (capable of self-renewal and differentiate into different lineages) and with increased genomic instability-bearing cells.
Islam, Farhadul
core   +1 more source

APOBEC3 activity and DNA polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations. [PDF]

Mol Oncol
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Butler KE, Lone BA, Unal E, Banday AR.
europepmc   +2 more sources

VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance

Signal Transduction and Targeted Therapy, 2021
Radiotherapy remains the mainstay for treatment of various types of human cancer; however, the clinical efficacy is often limited by radioresistance, in which the underlying mechanism is largely unknown.
Weiling Liu, Chuanwang Miao, Shaosen Zhang, Yachen Liu, Xiangjie Niu, Yiyi Xi, Wenjia Guo, Jiahui Chu, Ai Lin, Hongjin Liu, Xinyu Yang, Xinjie Chen, Ce Zhong, Yuling Ma, Yuqian Wang, Shihao Zhu, Shuning Liu, Wen Tan, Dongxin Lin, Chen Wu   +19 more
doaj   +1 more source

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

Frontiers in Microbiology, 2019
The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific microbiota in the tumor microenvironment is still unclear.
Xiao-Hui Chen, Xiao-Hui Chen, Xiao-Hui Chen, Ang Wang, Ang Wang, Ang Wang, Ai-Ning Chu, Ai-Ning Chu, Ai-Ning Chu, Yue-Hua Gong, Yue-Hua Gong, Yue-Hua Gong, Yuan Yuan, Yuan Yuan, Yuan Yuan   +14 more
doaj   +1 more source

Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases

Cancer Medicine, 2018
Gastric tumorigenesis is a multistep process initiated by chronic superficial gastritis (SG), followed by atrophic gastritis (AG), then intestinal metaplasia (IM), and finally by dysplasia and adenocarcinoma according to the Correa model.
Jingyi Jiang, Shixuan Shen, Nannan Dong, Jingwei Liu, Qian Xu, Liping Sun, Yuan Yuan   +6 more
doaj   +1 more source

Data analysis in the post-genome-wide association study era

Chronic Diseases and Translational Medicine, 2016
Since the first report of a genome-wide association study (GWAS) on human age-related macular degeneration, GWAS has successfully been used to discover genetic variants for a variety of complex human diseases and/or traits, and thousands of associated ...
Qiao-Ling Wang, Wen-Le Tan, Yan-Jie Zhao, Ming-Ming Shao, Jia-Hui Chu, Xu-Dong Huang, Jun Li, Ying-Ying Luo, Lin-Na Peng, Qiong-Hua Cui, Ting Feng, Jie Yang, Ya-Ling Han   +12 more
doaj   +1 more source

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

BMC Cardiovascular Disorders, 2018
Background Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patients, and the performance of serum ...
Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin, Yuan Yuan   +6 more
doaj   +1 more source

Childhood, adolescent and young adult cancer: cancer trends report

, 2023
This is the third Cancer Trends Report the National Cancer Registry Ireland (NCRI) has published on childhood cancers and the first to include cancers in adolescents and young adults (AYA) (up to 24 years of age).
National Cancer Registry Ireland (NCRI)
core  

HER3 Is an Actionable Target in Advanced Prostate Cancer.

, 2021
It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically.
Bertan, C, Crespo, M, Guo, C, D'Ambrosio, M, Sharp, A, Rekowski, J, Swain, A, Carreira, S, Paschalis, A, Troiani, M, Ning, J, Gurel, B, de Bono, J, Sumanasuriya, S, PCF/SU2C International Prostate Cancer Dream Team,, Gil, V, Christova, R, Califano, A, Seed, G, Brina, D, Workman, P, Vasciaveo, A, Pereira, R, Dolling, D, Yuan, W, Flohr, P, Sheehan, B, Fowler, G, Rescigno, P, Neeb, A, Ferreira, A, Riisnaes, R, Alajati, A, Alimonti, A, Miranda, S, Buroni, L, Tunariu, N, Lambros, M, Aversa, C, Figueiredo, I, Shen, MM, Bianchini, D, Welti, J, Clarke, M, Boysen, G   +44 more
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source