Results 141 to 150 of about 482,699 (357)

Cancer Immunotherapy: Facts and Fancy [PDF]

, 1979
E. Benjamini, D Rennick
openalex   +1 more source

TOP: Time-to-Event Bayesian Optimal Phase II Trial Design for Cancer Immunotherapy [PDF]

arXiv, 2018
Immunotherapies have revolutionized cancer treatment. Unlike chemotherapies, immune agents often take longer time to show benefit, and the complex and unique mechanism of action of these agents renders the use of multiple endpoints more appropriate in some trials.
arxiv  

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Therapeutic Vaccine Strategies against Human Papillomavirus

Vaccines, 2014
High-risk types of human papillomavirus (HPV) cause over 500,000 cervical, anogenital and oropharyngeal cancer cases per year. The transforming potential of HPVs is mediated by viral oncoproteins.
Hadeel Khallouf, Agnieszka K. Grabowska, Angelika B. Riemer   +2 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Phase I study of the adoptive immunotherapy of human cancer with lectin activated autologous mononuclear cells [PDF]

, 1984
Amitabha Mazumder, Timothy J. Eberlein, Elizabeth A. Grimm, Debra J. Wilson, Andrew M. Keenan, Roger Aamodt, Steven A. Rosenberg   +6 more
openalex   +1 more source

The LILRB family in hematologic malignancies: prognostic associations, mechanistic considerations, and therapeutic implications

Biomarker Research
The leukocyte immunoglobulin-like receptor B (LILRB) proteins, characterized by their transmembrane nature and canonical immunoreceptor tyrosine-based inhibitory motifs (ITIM) signaling, play a pivotal role in maintaining immune homeostasis and are ...
Alan Hodges, Rachel Dubuque, Shu-Hsia Chen, Ping-Ying Pan   +3 more
doaj   +1 more source

Circulating IL-6 and not its circulating signaling components sIL-6R and sgp130 demonstrate clinical significance in NSCLC patients treated with immune checkpoint inhibitors

Frontiers in Cell and Developmental Biology
Introduction: Clinical roles of plasma IL-6 levels have been reported in patients with various cancers, including non-small cell lung cancer (NSCLC), treated with immune checkpoint inhibitors (ICIs). However, the roles of other IL-6 signaling components,
Yoshiro Nakahara, Yoshiro Nakahara, Taku Kouro, Taku Kouro, Satoru Motoyama, Satoru Motoyama, Satoru Motoyama, Masatomo Miura, Kazuma Fujita, Yuka Igarashi, Naoko Higashijima, Norikazu Matsuo, Hidetomo Himuro, Hidetomo Himuro, Feifei Wei, Feifei Wei, Shun Horaguchi, Shun Horaguchi, Shun Horaguchi, Kayoko Tsuji, Kayoko Tsuji, Yasunobu Mano, Yasunobu Mano, Mitsuru Komahashi, Mitsuru Komahashi, Mitsuru Komahashi, Haruhiro Saito, Koichi Azuma, Tetsuro Sasada, Tetsuro Sasada   +29 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types

Nature Communications
Identifying tumor-specific T cell clones that mediate immunotherapy responses remains challenging. Mutation-associated neoantigen (MANA) -specific CD8+ tumor-infiltrating lymphocytes (TIL) have been shown to express high levels of CXCL13 and CD39 (ENTPD1)
Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith   +18 more
doaj   +1 more source