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2018
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1 ...
Sminu, Bose, Anne, Le
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Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1 ...
Sminu, Bose, Anne, Le
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Surgical Clinics of North America, 1986
Progressive weight loss and anorexia are frequent phenomena in cancer patients. Although cachexia is an expected occurrence in the terminal stages of nearly all malignancies, it may be a presenting sign when the tumor burden is quite small. Lipid depletion occurs out of proportion to the protein loss and accounts for most of the weight loss in cancer ...
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Progressive weight loss and anorexia are frequent phenomena in cancer patients. Although cachexia is an expected occurrence in the terminal stages of nearly all malignancies, it may be a presenting sign when the tumor burden is quite small. Lipid depletion occurs out of proportion to the protein loss and accounts for most of the weight loss in cancer ...
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Mevalonate metabolism in cancer
Cancer Letters, 2015Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to ...
Georg, Gruenbacher, Martin, Thurnher
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The FEBS Journal, 2012
Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides, phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular and organismal levels. Fatty acids are the major building blocks for the synthesis of triacylglycerides, which are mainly used for energy storage.
Claudio R, Santos, Almut, Schulze
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Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides, phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular and organismal levels. Fatty acids are the major building blocks for the synthesis of triacylglycerides, which are mainly used for energy storage.
Claudio R, Santos, Almut, Schulze
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Cold Spring Harbor Perspectives in Medicine
Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public interest, there are limited defined diet and exercise regimens for cancer patients.
Jason W. Locasale +3 more
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Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public interest, there are limited defined diet and exercise regimens for cancer patients.
Jason W. Locasale +3 more
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Methionine metabolism and cancer
Nutrition and Cancer, 1985This paper summarizes recent developments linking methionine metabolism and S-adenosylmethionine to DNA methylation and gene expression in relation to cancer. Methionine, obtained in the diet and synthesized by several reactions in the body, is the sole precursor of S-adenosylmethionine, the primary methyl donor in the body.
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Cold Spring Harbor Perspectives in Medicine
Metabolic reprogramming in cancer allows cells to survive in harsh environments and sustain macromolecular biosynthesis to support proliferation. In addition, metabolites play crucial roles as signaling molecules. Metabolite fluctuations are detected by various sensors in the cell to regulate gene expression, metabolism, and signal transduction ...
Laura V, Pinheiro +2 more
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Metabolic reprogramming in cancer allows cells to survive in harsh environments and sustain macromolecular biosynthesis to support proliferation. In addition, metabolites play crucial roles as signaling molecules. Metabolite fluctuations are detected by various sensors in the cell to regulate gene expression, metabolism, and signal transduction ...
Laura V, Pinheiro +2 more
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Cancer is a metabolic deficiency
Medical Hypotheses, 1986Cancer is regarded here as a metabolic deficiency originating in stem cell destruction. Tissue stem cells are postulated to secrete a vital substance 'A' necessary for proper tissue function. Carcinogens interfere with 'A' production mainly by destroying stem cells which the organism is incapable of fully replenishing so that less 'A' is produced. This
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Cancer Metabolism: Targeting metabolic pathways in cancer therapy
Cancer Letters, 2015Shree Ram, Singh +2 more
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021David Kirsch +2 more
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