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Molecular Cell, 2021
Metabolic networks support cancer cell survival, proliferation, and malignant progression. Cancer cells take up large amounts of nutrients such as glucose and glutamine whose metabolism provides the energy, reducing equivalents, and biosynthetic precursors required to meet the biosynthetic demands of proliferation.
Julia S, Brunner, Lydia W S, Finley
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Metabolic networks support cancer cell survival, proliferation, and malignant progression. Cancer cells take up large amounts of nutrients such as glucose and glutamine whose metabolism provides the energy, reducing equivalents, and biosynthetic precursors required to meet the biosynthetic demands of proliferation.
Julia S, Brunner, Lydia W S, Finley
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Glutamine Metabolism in Cancer
2018Metabolism is the fundamental process for all cellular functions. For decades, there has been growing evidence with regard to the relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, however, cancer cells have reprogrammed metabolisms in order to fulfill their energy requirements.
Ting, Li, Anne, Le
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Methionine metabolism and cancer
Nutrition and Cancer, 1985This paper summarizes recent developments linking methionine metabolism and S-adenosylmethionine to DNA methylation and gene expression in relation to cancer. Methionine, obtained in the diet and synthesized by several reactions in the body, is the sole precursor of S-adenosylmethionine, the primary methyl donor in the body.
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Surgical Clinics of North America, 1986
Progressive weight loss and anorexia are frequent phenomena in cancer patients. Although cachexia is an expected occurrence in the terminal stages of nearly all malignancies, it may be a presenting sign when the tumor burden is quite small. Lipid depletion occurs out of proportion to the protein loss and accounts for most of the weight loss in cancer ...
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Progressive weight loss and anorexia are frequent phenomena in cancer patients. Although cachexia is an expected occurrence in the terminal stages of nearly all malignancies, it may be a presenting sign when the tumor burden is quite small. Lipid depletion occurs out of proportion to the protein loss and accounts for most of the weight loss in cancer ...
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Cancer metabolism: looking forward
Nature Reviews. Cancer, 2021I. Martínez-Reyes, N. Chandel
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Mevalonate metabolism in cancer
Cancer Letters, 2015Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to ...
Georg, Gruenbacher, Martin, Thurnher
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Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review.
Seminars in Cancer Biology, 2020Several signaling pathways and basic metabolites are responsible for the control of metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism, the abnormal activities of these pathways are of the most noticeable events in ...
S. Fakhri +3 more
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The FEBS Journal, 2012
Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides, phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular and organismal levels. Fatty acids are the major building blocks for the synthesis of triacylglycerides, which are mainly used for energy storage.
Claudio R, Santos, Almut, Schulze
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Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides, phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular and organismal levels. Fatty acids are the major building blocks for the synthesis of triacylglycerides, which are mainly used for energy storage.
Claudio R, Santos, Almut, Schulze
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Cancer cell metabolism in tumor-targeting immunity
Nature reviews. ImmunologyAccumulating evidence suggests that metabolic rewiring in malignant cells supports tumour progression not only by providing cancer cells with increased proliferative potential and an improved ability to adapt to adverse microenvironmental conditions but ...
M. De Martino +3 more
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The metabolic environment of cancer
Molecular and Cellular Biochemistry, 1988The tumor cell has a very distinctive metabolism. It acts as a metabolic trap for host nutrients thus taking vital compounds for the metabolism of the host. Depending on the particular tumor growing pattern, cancer cells use preferentially glucose or amino acids for their energetic or biosynthetic needs.
J M, Argilés, J, Azcón-Bieto
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