Results 101 to 110 of about 897,136 (317)

Talin1 Promotes Prostate Cancer Invasion and Metastasis via AKT Signaling and Anoikis Resistance

, 2009
Talin1 is an integrin regulatory protein that mediates integrin interactions with the extracellular matrix (ECM). This study investigated the significance of talin1 in prostate cancer progression to metastasis in vitro and in vivo.
Natasha Kyprianou, Shinichi Sakamoto, Richard McCann   +2 more
core  

Outcomes of Brain Metastasis from Lung Cancer

Background/Objectives: Little information has been published on patients diagnosed with brain metastasis secondary to lung cancer. Correlating outcome patterns (hospice care, lost to follow-up, death before hospice care or treatment) and specific ...
James M. Mobley, Bin Huang, Laurie E. McLouth, John L. Villano, Niharika Reddy, Quan Chen, Julia B. Magsam, Ellen Reusch, Kerry I. Phillips   +8 more
core   +1 more source

What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data? [PDF]

, 2013
Breast cancer patients have an anomalously high rate of relapse many years-up to 25 years-after apparently curative surgery removed the primary tumour.
Karen M Page, Alarcón, T, Tomlinson, IP, Page, KM, Lisa Willis (410078), Tomás Alarcón (224873), Ian P. M. Tomlinson (218767), Tomlinson Ian P. M., Karen M. Page (410080), Trevor A Graham, Alison Malcolm R., Alarcón Tomás, Page Karen M., Tomás Alarcón, Malcolm R. Alison (201259), Willis Lisa, Trevor A. Graham (410079), Graham, TA, Alison, MR, Malcolm R Alison, Tomlinson, IPM, Willis, L, Lisa Willis, Graham Trevor A., Ian P M Tomlinson   +24 more
core   +1 more source

LincRNA01703 Facilitates CD81+ Exosome Secretion to Inhibit Lung Adenocarcinoma Metastasis via the Rab27a/SYTL1/CD81 Complex

, 2023
Metastasis, a major cause of cancer-related mortality worldwide, frequently occurs early in the diagnosis of lung adenocarcinoma (LUAD). However, the precise molecular mechanisms governing the aggressive metastatic behavior of LUAD remain incompletely ...
Junchao Cai, Tianyu Tao, Jie Yuan, Weibin Wu, Shan Guo, Guoyong Wu, Liyun Huo, Hongmei Yan, Zishuo Chen, Yun Huang, Hongyu Guan, Jueheng Wu, Ying Lin, Zhanwen Lin   +13 more
core   +1 more source

ICG combined with medical adhesive in preoperative localization of complex pulmonary nodules: a retrospective study

BMC Medical Imaging
Background Precise pulmonary nodule localization, especially for deep-seated or pleural-adherent lesions, remains challenging. Conventional methods face accuracy limitations and high complication rates. This study validates a CT-guided indocyanine green (
Wenhao Wang, Yulong Tan, Dong Xu, Haoxin Liu, Yifeng Qian, Huijun Zhang, Meng Shi, Xiaofeng Chen   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Role of Post-Translational Modifications in Colorectal Cancer Metastasis

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC ...
Yihong Liu, Haibo Zhao, Jingwei Liu, Weixin Liu, Shuangshuang Hai, Na Peng   +5 more
core   +1 more source

Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis

Oncogenesis, 2023
Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines

Cell Communication and Signaling
Background Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments.
Sandy Anania, Martin Farnir, Raphaël Peiffer, Yasmine Boumahd, Marc Thiry, Ferman Agirman, Naima Maloujahmoum, Akeila Bellahcène, Olivier Peulen   +8 more
doaj   +1 more source