Results 171 to 180 of about 3,398,816 (318)

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Mortality Data Collection by Local Authorities Compared to a Cancer Registry. [PDF]

Dtsch Arztebl Int
Hovanec J, Stang A, Kajüter H, Darwiche K, Bölükbas S, Theegarten D, Brüning T, Behrens T.   +7 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Providing a Conceptual Object-Oriented Model for Hospital-Based Colorectal Cancer Registry: Cross-Sectional Study. [PDF]

Health Sci Rep
Sheykhmohammadi N, Rabiei R, Emami H, Moghaddasi H.   +3 more
europepmc   +1 more source

Cancer Registry [PDF]

, 2020
openaire   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Receipt of Cancer Surgery: A Comparison of Cancer Registry Data and Medicare Claims. [PDF]

Med Care
Hong YD, Enewold L, Zeruto CA, Mariotto AB.   +3 more
europepmc   +1 more source

National Cancer Survivorship Needs Assessment: The Unmet Needs of Cancer Survivors in Ireland: A Scoping Review 2019

, 2019
This review showed that there has not been a lot of research in this area previously. Most of the research looked at the more common cancers in Ireland, such as prostate, colorectal, and breast.
Donnelly, Conan, O'Connor, Mairead, O'Donovan, Bernadine, Drummond, Frances, National Cancer Registry Ireland (NCRI), Irish Cancer Society   +5 more
core  

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Portuguese National Cancer Registry: from local registries to high-quality nationwide real-world data. [PDF]

ESMO Real World Data Digit Oncol
Garcia TM, Sousa A, Leite-Silva P, Lopes-Conceição L, Godinho O, Bento MJ.   +5 more
europepmc   +1 more source