Results 1 to 10 of about 1,708,228 (211)

Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer

open access: yesJournal of Immunology Research, 2021
Colorectal cancer (CRC) has two major subtypes, microsatellite instability (MSI) and microsatellite stability (MSS) based on the genomic instability. In this study, using computational programs, we identified 9 master transcription factors (TFs) based on
Qian Yang   +4 more
doaj   +1 more source

Guide to Metabolomics Analysis: A Bioinformatics Workflow

open access: yesMetabolites, 2022
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The key purpose of metabolomics is to identify the metabolites corresponding to each biological phenotype, and then provide an analysis of the mechanisms involved ...
Yang Chen, En-Min Li, Li-Yan Xu
doaj   +1 more source

Alterations of RNA splicing patterns in esophagus squamous cell carcinoma

open access: yesCell & Bioscience, 2021
Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding   +13 more
doaj   +1 more source

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

open access: yesCell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng   +10 more
doaj   +1 more source

Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer

open access: yesFrontiers in Molecular Biosciences, 2021
Annexin A3 (ANXA3), also known as lipocortin III and placental anticoagulant protein III, has been reported to be dysregulated in tumor tissues and cancer cell lines, and harbors pronounced diagnostic and prognostic value for certain malignancies, such ...
Liu Yang   +4 more
doaj   +1 more source

Cancer incidence in hypertensives [PDF]

open access: yesCancer, 1987
Cancer incidence was measured over a 5-year period (1978 to 1982) in 4067 hypertensive patients, and 10,366 normotensive patients from general practices in southwestern Ontario. For cancer of all sites an elevated incidence was found among hypertensive patients.
C, Buck, A, Donner
openaire   +2 more sources

Longitudinal trends in prostate cancer incidence, mortality, and survival of patients from two Shanghai city districts: a retrospective population-based cohort study, 2000-2009. [PDF]

open access: yes, 2014
BackgroundProstate cancer is the fifth most common cancer affecting men of all ages in China, but robust surveillance data on its occurrence and outcome is lacking. The specific objective of this retrospective study was to analyze the longitudinal trends
Deng, Haiju   +5 more
core   +7 more sources

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression

open access: yesFrontiers in Immunology, 2022
ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang   +9 more
doaj   +1 more source

THE AGE INCIDENCE OF CANCER. [PDF]

open access: yesThe Lancet, 1905
n ...
Roberts, R. E., Wilson, ArthurC
openaire   +2 more sources

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

open access: yesNature Communications, 2021
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival ...
Wei Liu   +23 more
doaj   +1 more source

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