Results 41 to 50 of about 4,964,098 (260)

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Increased KCNQ3 expression in papillary thyroid cancer promotes proliferation and migration

Cancer Cell International
Purpose Papillary thyroid cancer (PTC), the most prevalent thyroid malignancy, is witnessing a global surge in incidence. The potassium voltage-gated channel subfamily Q member 3 (KCNQ3) is aberrantly overexpressed in PTC, yet its mechanistic ...
Qiuli Li, Muyuan Liu, Xuhong Song, Lingzhu Xie, Dongchen Liu, Ting Su, Yangzhan Xu, Gengquan Li, Bin Liang, Dongyang Huang   +9 more
doaj   +1 more source

Cancer incidence and mortality in France over the period 1980-2005.

, 2008
BACKGROUND: The objective of this study was to provide updated estimates of national trends in cancer incidence and mortality for France for 1980-2005. METHODS: Twenty-five cancer sites were analysed.
Belot, A, Troussard, Xavier,, Bara, S, Hédelin, G, Raverdy, Nicole, Daubisse, L, Collignon, A, Arveux, Patrick, Trétarre, B, Faivre, Jean, Chérié-Challine, Laurence, Velten, M., Grosclaude, P, Colonna, Marc, Delafosse, Patricia, Monnereau, A, Benhamou, Ellen, Bovet, Martine, Molinié, F, Janoray, I, Bouvier, Anne Marie, Launoy, G, Grosclaude, Pascale, Bara, Simona, Monnereau, Alain, A., Troussard, Xavier, X., Le Stang, N, Maynadié, Marc, Janoray, Inès, Daubisse, Laetitia, Delafosse, P, Estève, J, Faivre, J, Monnereau, Alain,, Esteve, Jaume, Schvartz, C, Trétarre, Brigitte, Colonna, M, Bovet, M, Binder-Foucard, F, Bouvier, A-M, Hédelin, Guy, Collignon, Anne, Maynadié, M, Molinié, Florence, Remontet, L, Buemi, A, Belot, Aurélien, Schvartz, Claire, Launoy, Guy, Jougla, Eric, Danzon, Arlette, Troussard, X, Bossard, N, Guizard, A-V, Arveux, P, Jougla, E, Le Stang, Nolwenn, Benhamou, E, Raverdy, N, Binder-Foucard, Florence, Danzon, A, Velten, M, Guizard, Anne Valérie, Chérié-Challine, L, Remontet, L., Buemi, Antoine, Bossard, Nadine   +67 more
core   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

The effectiveness of problem-based learning (PBL) in enhancing critical thinking skills in medical education: a systematic review and meta-analysis

Frontiers in Education
BackgroundProblem-based learning (PBL) has emerged as a transformative educational strategy aimed at enhancing critical thinking in medical education.
Ting Su, Jing Liu, Lele Meng, Yijing Luo, Qiaoling Ke, Lingzhu Xie, Lingzhu Xie   +6 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression

Nature Communications
Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been fully understood.
Yu-Fei Cao, Hui Wang, Yong Sun, Bei-Bei Tong, Wen-Qi Shi, Liu Peng, Yi-Meng Zhang, Yu-Qiu Wu, Teng Fu, Hua-Yan Zou, Kai Zhang, Li-Yan Xu, En-Min Li   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells

Cell Death and Disease
The translesion DNA synthesis (TLS) pathway mediated by proliferating cell nuclear antigen (PCNA) monoubiquitination is an essential mechanism by which cancer cells bypass DNA damage caused by DNA damage to maintain genomic stability and cell survival ...
Bing Wen, Hai-Xiang Zheng, Jing-Hua Heng, Qian Tang, Dan-Xia Deng, Zhi-Da Zhang, Lian-Di Liao, Li-Yan Xu, En-Min Li   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source