Results 61 to 70 of about 52,240,321 (193)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Highlights of prostate cancer research in Ireland

, 2010
Summary document highlighting prostate cancer research in Ireland.The publication of this report was supported by an educational grant from ...
Prostate Cancer Research Consortium
core  

Click Chemistry in Human Cancer Research

Zhongliu Fangzhi Yanjiu
As one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-Fungible Tokens for Organoids: Decentralized Biobanking to Empower Patients in Biospecimen Research

Blockchain in Healthcare Today
Introduction: Scientists use donated biospecimens to create organoids, miniature copies of patient tumors1 that are revolutionizing precision medicine2 and drug discovery.
William Sanchez, Larue Linder, Robert Miller,, Amelia Hood, Marielle Gross   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Non-selective Primary Human Tumor Cell Line Generation from Surgical Resections to be Paired With Flash Frozen and Paraffin Embedded Tissue: Advancements in Democratizing Translational Research Materials to Rural Institutions

Marshall Journal of Medicine, 2021
Translational cancer research relies on the availability of human patient tissue demonstrating the specific disease process under investigation. Biobanks of human tissue have historically been and remain to date the primary access point for cancer ...
Jennifer Hawkins, Rebecca Russell, Logan Lawrence, Amrita Valluri, Jessica Wellman, Krista Denning   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Abstracts of the XI Forum on Translational Immunology and Cancer Immunotherapy (FIT Cancer 11)

Medical Sciences Forum
The Spanish Group for Cancer Immuno-Biotherapies (GÉTICA) held the XI Forum on Translational Immunology and Cancer Immunotherapy (FIT Cancer 11) from 13 to 15 March 2025, in Madrid (Spain).
Francisco Aya, Luis de la Cruz, Delvys Rodríguez-Abreu, Luis Álvarez-Vallina, Manel Juan, Elisabeth Pérez-Ruiz, Xabier Mielgo, Rodolfo Chicas-Sett, Ana Arance   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source