Results 81 to 90 of about 24,047,971 (353)

Integration of Online Omics-Data Resources for Cancer Research

Frontiers in Genetics, 2020
The manifestations of cancerous phenotypes necessitate alterations at different levels of information-flow from genome to proteome. The molecular alterations at different information processing levels serve as the basis for the cancer phenotype to emerge.
Tonmoy Das, G. Andrieux, Musaddeque Ahmed, Sajib Chakraborty   +3 more
semanticscholar   +1 more source

Update on pathology laboratory development and research in advancing regional cancer care in Malawi

Frontiers in Medicine
The pathology laboratory at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi was established in 2011. We published our initial experiences in laboratory development and telepathology in 2013 and 2016, respectively.
Amy J. Brownlee, Morgan Dewey, Maganizo B. Chagomerana, Maganizo B. Chagomerana, Tamiwe Tomoka, Maurice Mulenga, Shiraz Khan, Shiraz Khan, Coxcilly Kampani, Fred Chimzimu, Julie M. Gastier-Foster, Kate D. Westmoreland, Kate D. Westmoreland, Kate D. Westmoreland, Nmazuo W. Ozuah, Robert Krysiak, Chikondi Malamba-Banda, Chikondi Malamba-Banda, Chikondi Malamba-Banda, Matthew S. Painschab, Matthew S. Painschab, Matthew S. Painschab, Satish Gopal, Yuri Fedoriw, Yuri Fedoriw, Yuri Fedoriw   +25 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Cancer survivorship: an integral part of Europe's research agenda

Molecular Oncology, 2019
Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers’ efforts.
Pernilla Lagergren, Anna Schandl, Neil K. Aaronson, Hans‐Olov Adami, Francesco deLorenzo, Louis Denis, Sara Faithfull, Lifang Liu, Franḉoise Meunier, Cornelia Ulrich, the European Academy of Cancer Sciences   +10 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Further Guidance in Implementing the Standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score

Cancer Epidemiology, Biomarkers and Prevention, 2020
The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score was developed to establish a simple, standardized scoring system for researchers to quantify adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations ...
Marissa M. Shams-White, D. Romaguera, P. Mitrou, J. Reedy, A. Bender, N. Brockton   +5 more
semanticscholar   +1 more source

Personalizing Therapy Outcomes through Mitogen-Activated Protein Kinase Pathway Inhibition in Non-Small Cell Lung Cancer

Biomedicines
Lung cancer (LC) is a highly invasive malignancy and the leading cause of cancer-related deaths, with non-small cell lung cancer (NSCLC) as its most prevalent histological subtype.
Hasan Alsharoh, Paul Chiroi, Ekaterina Isachesku, Radu Andrei Tanasa, Ovidiu-Laurean Pop, Radu Pirlog, Ioana Berindan-Neagoe   +6 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source