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Hallmarks of cancer resistance. [PDF]
iScienceThis review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized by the Warburg effect, and the dynamic interplay between cancer cells and mitochondria. The role of cancer stem cells (CSCs) in treatment resistance and the regulatory influence of non-
Tufail M +8 more
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Hypoxia-Induced Reactive Oxygen Species: Their Role in Cancer Resistance and Emerging Therapies to Overcome It [PDF]
AntioxidantsNormal tissues typically maintain partial oxygen pressure within a range of 3–10% oxygen, ensuring homeostasis through a well-regulated oxygen supply and responsive vascular network.
Eleicy Nathaly Mendoza +2 more
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Cholesterol Synthesis Is Important for Breast Cancer Cell Tumor Sphere Formation and Invasion
Biomedicines, 2022 Breast cancer has a high risk of recurrence and distant metastasis after remission. Controlling distant metastasis is important for reducing breast cancer mortality, but accomplishing this goal remains elusive.
Hee Yeon Kim +6 more
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Journal of Experimental & Clinical Cancer Research, 2022 Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez +20 more
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Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology
Frontiers in Oncology, 2021 Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic ...
Elisabet Cuyàs +7 more
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Cells, 2021 Tremendous data have been accumulated in the effort to understand chemoresistance of triple negative breast cancer (TNBC). However, modifications in cancer cells surviving combined and sequential treatment still remain poorly described. In order to mimic
Marie Winter +9 more
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Multidrug resistance in cancer [PDF]
BMJ, 1994 Malignant neoplasms vary in their response to cytotoxic drugs: some are sensitive, others resistant. Understanding of the biochemical basis of this resistance might lead to the development of markers that would correlate with the clinical response to the drugs - or even lead to ways of overcoming the resistance.
D R, Ferry, D J, Kerr
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miR-92a-3p regulates cisplatin-induced cancer cell death
Cell Death and Disease, 2023 Non-small cell lung cancer is characterized by a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Therefore, the identification of new molecular determinants underlying sensitivity of cancer cells to existing therapy
Romain Larrue +11 more
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The Versatile Role of miR-21 in Renal Homeostasis and Diseases
Cells, 2022 MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have ...
Romain Larrue +8 more
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ALDH1: A potential therapeutic target for cancer stem cells in solid tumors
Frontiers in Oncology, 2022 Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer
Yaolu Wei +13 more
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