Results 21 to 30 of about 2,125,565 (269)

RnBeads 2.0: comprehensive analysis of DNA methylation data

Genome Biology, 2019
DNA methylation is a widely investigated epigenetic mark with important roles in development and disease. High-throughput assays enable genome-scale DNA methylation analysis in large numbers of samples.
Fabian Müller, Michael Scherer, Yassen Assenov, Pavlo Lutsik, Jörn Walter, Thomas Lengauer, Christoph Bock   +6 more
doaj   +1 more source

A randomised comparison of UK genetic risk counselling services for familial cancer: psychosocial outcomes [PDF]

, 2004
The aim of the study was to compare psychosocial outcomes for 50 new clinic attendees, referred for cancer genetic counselling to five UK centres. The centres represented England, Scotland and Wales, and were randomly selected from groups ranked by ...
Wonderling, D., Gray, J, Eccles, D, Steel, Michael, McPherson, K., D Eccles, D Wonderling, Murday, V, Eccles, D., McPherson, K, Wonderling, D, V Murday, Steel, M., P Hopwood, Hopwood, P, Watson, M., Douglas, F., A Cull, Steel, M, Douglas, F, Cole, T., Watson, M, K McPherson, Gray, J., Murday, V., F Douglas, Cull, A., T Cole, J Burn, Cole, T, Hopwood, P., J Gray, Burn, J., Cull, A, M Steel, Burn, J, Gray, Jonathon, M Watson   +37 more
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Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer

OncoImmunology, 2017
Kynurenine formation by tryptophan-catabolic indoleamine-2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune evasion and inhibition of IDO1 is efficacious in preclinical models of breast cancer. As the response of breast cancer to immune checkpoint
Dyah L. Dewi, Soumya R. Mohapatra, Saioa Blanco Cabañes, Isabell Adam, Luis F. Somarribas Patterson, Bianca Berdel, Masroor Kahloon, Loreen Thürmann, Stefanie Loth, Katharina Heilmann, Dieter Weichenhan, Oliver Mücke, Ines Heiland, Pauline Wimberger, Jan Dominik Kuhlmann, Karl-Heinz Kellner, Sarah Schott, Christoph Plass, Michael Platten, Clarissa Gerhäuser, Saskia Trump, Christiane A. Opitz   +21 more
doaj   +1 more source

Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved [PDF]

, 2011
Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer ...
Bastide, Nadia, Nadia M. Bastide, Denis E. Corpet, Pierre, Fabrice, Pierre, Fabrice H.F., Corpet, Denis E., Fabrice H.F. Pierre   +6 more
core   +1 more source

Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls

Journal of Nucleic Acids, 2010
Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer ...
Marco Peluso, Armelle Munnia, Sara Piro, Alessandra Armillis, Marcello Ceppi, Giuseppe Matullo, Riccardo Puntoni   +6 more
doaj   +1 more source

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.

, 2007
Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility.
Pharoah, Paul DP, Hogervorst, Frans BL, Dunning, Alison M, Nevanlinna, Heli A, Blomqvist, Carl,, Tommiska, Johanna, Healey, Catherine S, Pharoah, Paul D P, Tollenaar, Rob A E M, Reincke, Scarlett, Peto, Julian, Blomqvist, Carl, Van't Veer, Laura J, Johnson, Nichola, Fletcher, Olivia, Tollenaar, Rob AEM, Broeks, Annegien, Schmidt, Marjanka K, Braaf, Linde M, Hogervorst, Frans B L, Breast Cancer Association Consortium, Easton, Douglas F, Dörk, Thilo   +22 more
core   +1 more source

Trends in the lifetime risk of developing cancer in Great Britain: comparison of risk for those born from 1930 to 1960 [PDF]

, 2015
Background: Typically, lifetime risk is calculated by the period method using current risks at different ages. Here, we estimate the probability of being diagnosed with cancer for individuals born in a given year, by estimating future risks as the cohort
Ahmad, AS, Ahmad, A. S., Ormiston-Smith, N, A S Ahmad, P D Sasieni, Sasieni, PD, Ormiston-Smith, N., Sasieni, P. D.; id_orcid, N Ormiston-Smith   +8 more
core   +1 more source

A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data [PDF]

, 2020
Background: A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy.
Schaid, DJ, Khaw, K-T, Cannon-Albright, LA, Parsons, JK, Maier, C, Wokolorczyk, D, Dale, AM, Mills, IG, Vogel, W, Paulo, P, PRACTICAL Consortium,, Kote-Jarai, Z, Andreassen, OA, Brenner, H, Tammela, TL, Pharoah, PDP, Kaneva, RP, Kibel, AS, Teixeira, MR, Al Olama, AA, Cybulski, C, Aly, M, Mitev, VI, Key, TJ, Schöttker, B, Muir, K, Tammela, TLJ, Australian Prostate Cancer BioResource (APCB),, Martin, RM, Nordestgaard, BG, Maia, S, Pashayan, N, Sipeky, C, Slavov, CK, Karunamuni, R, Thibodeau, SN, Clements, JA, Wiklund, F, Gronberg, H, Lin, H-Y, Mitev, V, Pandha, H, Hamdy, FC, Donovan, JL, Luedeke, M, Walsh, E, Neal, DE, Kluzniak, W, Seibert, TM, Eeles, RA, Sellers, TA, Park, JY, Lane, JA, Fan, CC, Herkommer, K, Batra, J, Amin Al Olama, A, Turner, EL, Benlloch Garcia, S, Schleutker, J, Spurdle, AB, Michael, A, Walsh, EI, Easton, DF, McDonnell, SK, Garcia, SB, Ben, S, Holleczek, B, Travis, RC, Pharoah, PD, Huynh-Le, M-P   +70 more
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Maternal pelvic size not predictive of daughter's breast cancer or ovarian cancer in a large Swedish cohort. [PDF]

, 2009
Recent studies from Finland reported that maternal pelvic size predicted daughters' breast and ovarian cancer, possibly because maternal pelvic size is a marker for in utero hormone exposure.
Goodman, Anna, Silva, Isabel dos Santos, Silva Idos, S., Mishra, G.D., Koupil, Ilona,, Mishra, Gita D, Koupil, Ilona, Silva, Isabel D., Mishra, Gita D.   +8 more
core   +1 more source

The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults: results from the Korean National Health and Nutrition Examination Survey 2008–2013

BMC Public Health, 2017
Background Abnormalities in the clinical markers of metabolic syndrome (MS) are associated with the development of cardiovascular disease, type 2 diabetes mellitus, and some cancers.
Binh Thang Tran, Bo Yoon Jeong, Jin-Kyoung Oh   +2 more
doaj   +1 more source