Results 41 to 50 of about 9,845,002 (301)

Hematologic toxicity in BRCA1 and BRCA2 mutation carriers during chemotherapy: A retrospective matched cohort study

Cancer Medicine, 2019
Women who inherit a BRCA1 or BRCA2 mutation have an increased risk of breast cancer. Preliminary evidence suggests they may also have defects in bone marrow function.
Allison H. West, Hayley Knollman, James Dugan, Donald Hedeker, Elisabeth A. Handorf, Sarah M. Nielsen, Lisa C. Bealin, Lindsay G. Goldblatt, Heather Willems, Mary B. Daly, Anosheh Afghahi, Olufunmilayo I. Olopade, Peter J. Hulick, Elena Shagisultanova, Dezheng Huo, Elias Obeid, Jane E. Churpek   +16 more
doaj   +1 more source

Vitamin D and Vitamin D‐binding protein and risk of bladder cancer: A nested case‐control study in the Norwegian Janus Serum Bank Cohort

Cancer Medicine, 2021
Background  High circulating levels of vitamin D (25(OH)D) are suggested to reduce the risk of urinary bladder cancer (BC), but the evidence is weak, and several studies lack sufficient adjustment for potential confounders (e.g., smoking, body mass index
Helga H. Hektoen, Trude E. Robsahm, Jo S. Stenehjem, Karol Axcrona, Ronnie Babigumira, Alison M. Mondul, Randi E. Gislefoss, Bettina K Andreassen   +7 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer. [PDF]

, 2003
We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 391 women with squamous cell ...
Mant, David, Chilvers, C, Green, Jane, P Jha, Green, J, C Chilvers, Sweetland, S, J Peto, Deacon, J, J Green, A Berrington de Gonzalez, Hermon, C, V Beral, Jha, P, S Sweetland, J Deacon, Mant, D, C Hermon, D Mant, Peto, J, M Pike, Vessey, MP, Sweetland, Sian, Crossley, B, M P Vessey, Pike, M, B Crossley, Beral, Valerie, Beral, V, Berrington de Gonzalez, A   +29 more
core   +1 more source

HEAVY METAL CONTENTS IN COMMERCIAL FISHES CONSUMED IN UMUAHIA AND THEIR ASSOCIATED HUMAN HEALTH RISKS

EQA, 2020
This study evaluated the heavy metal contents in commercial fishes consumed in Umuahia and their associated health consequences. Trachunis symmetricus, Clupia pallassi, Micropogonias undulatus, Ictalumus punctalus, Scomber japonicus, Merluccius paradoxus,
Robert Ikechukwu Uroko, Amarachi Agbafor, Simeon Ikechukwu Egba, Oluomachi Nancy Uchenna, Rose Simon Adeyi Sangodare, Chinedu Paulinus Nwuke, Osisioma Kenneth Nwanosike   +6 more
doaj   +1 more source

Public health risk associated with the co-occurrence of aflatoxin B1 and ochratoxin A in spices, herbs, and nuts in Lebanon

Frontiers in Public Health, 2023
BackgroundAflatoxin B1 and ochratoxin A are mycotoxins produced by filamentous fungi that attack crops on field and storage. Both mycotoxins present a risk on public health since aflatoxin B1 is a hepatotoxic and hepatocarcinogenic agent while ochratoxin
Rouaa Daou, Maha Hoteit, Maha Hoteit, Maha Hoteit, Maha Hoteit, Khlood Bookari, Khlood Bookari, Karine Joubrane, Lydia Rabbaa Khabbaz, Lydia Rabbaa Khabbaz, Ali Ismail, Richard G. Maroun, André el Khoury   +12 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Nature Communications, 2016
Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after ...
Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda   +18 more
doaj   +1 more source

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

Frontiers in Oncology, 2020
Cancer remains the second leading cause of mortality worldwide. In the course of this multistage and multifactorial disease, a set of alterations takes place, with genetic and environmental factors modulating tumorigenesis and disease progression ...
Lara P. Fernández, Marta Gómez de Cedrón, Ana Ramírez de Molina   +2 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source